Ruthenium-Catalyzed Regioselective Synthesis of C3-Alkylated Indoles Following Transfer Hydrogenation or Borrowing Hydrogen Strategy

被引：7

作者：

Chen, Xia ^{[1
,2
]}

Zhou, Xiao-Yu ^{[1
,2
]}

机构：

[1] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China

[2] Guizhou Key Lab Coal Clean Utilizat, Liupanshui 553004, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2023年 / 55卷 / 09期

基金：

中国国家自然科学基金;

关键词：

transfer hydrogenation; borrowing hydrogen; alkylation; indoles; alcohols; TRYPTAMINE DERIVATIVES; C-3; ALKYLATION; ALCOHOLS; METHYLATION; METHANOL; SUBSTITUTION; HOMOLOGS; KETONES;

D O I：

10.1055/a-2003-3207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By employing either borrowing hydrogen or transfer hydrogenation strategy, two straightforward [Ru(p-cymene)Cl-2](2)-catalyzed methods for regioselective synthesis of C3-alkylated indoles have been developed, utilizing alcohols as H atom donors or alkylating agents. The developed catalytic system could accommodate a broad substrate scope including primary/secondary aliphatic alcohols and substituted indoles, and in most cases providing good yields. Notable features of the developed system include high-activity, easy operation, and air atmosphere.

引用

页码：1460 / 1466

页数：7

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