Morphea after initiation of dupilumab in two pediatric atopic dermatitis patients

被引：2

作者：

Wang, Sonia ^{[1
,4
]}

Berry, Corbett T. ^{[2
]}

Treat, James R. ^{[2
,3
]}

Jen, Melinda ^{[2
,3
]}

机构：

[1] Univ Penn, Perelman Sch Med, Philadelphia, PA USA

[2] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA USA

[3] Childrens Hosp Philadelphia, Sect Pediat Dermatol, Philadelphia, PA USA

[4] Univ Penn, Perelman Sch Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

PEDIATRIC DERMATOLOGY | 2023年 / 40卷 / 03期

关键词：

atopic dermatitis; drug-related side effects and adverse reactions; localized scleroderma; Th1-Th2; balance; LOCALIZED SCLERODERMA; PROFILES; CYTOKINE; BLOOD; CELLS;

D O I：

10.1111/pde.15200

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Morphea is a rare multifactorial autoimmune disorder characterized by a complex and dynamic interplay between Th1 and Th2 signaling. Active clinical trials are currently investigating the safety and efficacy of dupilumab for the treatment of primary morphea. Here, we present two cases of morphea that developed in pediatric atopic dermatitis patients treated with dupilumab. These findings may support a causal relationship between IL-4 receptor blockade and the development of the early inflammatory phase of morphea.

引用

页码：540 / 543

页数：4

共 50 条

[41] Safety of dupilumab in patients with atopic dermatitis: expert opinion
Francuzik, Wojciech
Alexiou, Aikaterina
Worm, Margitta
EXPERT OPINION ON DRUG SAFETY, 2021, 20 (09) : 997 - 1004
[42] Dupilumab treatment trends among patients with atopic dermatitis
Schneeweiss, Maria
Schneeweiss, Sebastian
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2020, 29 : 277 - 277
[43] The evaluation of dupilumab treatment response in atopic dermatitis patients
Askin, Ozge
Yucesoy, Sera Nur
Serdaroglu, Server
NORTHERN CLINICS OF ISTANBUL, 2021, 8 (02) : 145 - 149
[44] Dupilumab for treatment of atopic dermatitis in patients living with HIV
Nusbaum, Kelsey
Kaffenberger, Benjamin
Paradiso, Michela
Sopkovich, Jennifer
Daou, Hala
Seminario-Vidal, Lucia
Trinidad, John
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2021, 85 (03) : AB126 - AB126
[45] Dupilumab in atopic dermatitis patients with chronic hepatitis B
Matsutani, Masako
Imai, Yasutomo
Nakatani-Kusakabe, Minori
Natsuaki, Masaru
Yamanishi, Kiyofumi
Kanazawa, Nobuo
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY, 2022, 5 (02) : 65 - 66
[46] Dupilumab in patients with atopic dermatitis: what effect on asthma?
Messekher, M.
Tauber, M.
Didier, A.
Guilleminault, L.
EUROPEAN RESPIRATORY JOURNAL, 2022, 60
[47] Dupilumab-Associated Conjunctivitis in Patients With Atopic Dermatitis
Liberman, Paulina
Shifera, Amde Selassie
Berkenstock, Meghan
CORNEA, 2020, 39 (06) : 784 - 786
[48] Is Dupilumab as Effective in Intrinsic Atopic Dermatitis as It Is in Extrinsic Atopic Dermatitis?
Gelato, Federica
Mastorino, Luca
Stepkina, Ekaterina
Cavaliere, Giovanni
Ribero, Simone
Quaglino, Pietro
Ortoncelli, Michela
JOURNAL OF CLINICAL MEDICINE, 2023, 12 (06)
[49] New-onset head and neck dermatitis in adolescent patients after dupilumab therapy for atopic dermatitis
Bax, Christina E.
Khurana, Michele C.
Treat, James R.
Castelo-Soccio, Leslie
Rubin, Adam I.
McMahon, Patrick J.
PEDIATRIC DERMATOLOGY, 2021, 38 (02) : 390 - 394
[50] Two differing presentations of periocular dermatitis as a side effect of dupilumab for atopic dermatitis
Yamane, Maya L. M.
Belsito, Donald V.
Glass, Lora R. Dagi
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY, 2019, 38 (05): : 390 - 394

← 1 2 3 4 5 →