Morphea after initiation of dupilumab in two pediatric atopic dermatitis patients

被引：2
|
作者：
Wang, Sonia [1 ,4 ]
Berry, Corbett T. [2 ]
Treat, James R. [2 ,3 ]
Jen, Melinda [2 ,3 ]
机构：
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA USA
[2] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA USA
[3] Childrens Hosp Philadelphia, Sect Pediat Dermatol, Philadelphia, PA USA
[4] Univ Penn, Perelman Sch Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA
来源：
PEDIATRIC DERMATOLOGY | 2023年 / 40卷 / 03期
关键词：
atopic dermatitis; drug-related side effects and adverse reactions; localized scleroderma; Th1-Th2; balance; LOCALIZED SCLERODERMA; PROFILES; CYTOKINE; BLOOD; CELLS;
D O I：
10.1111/pde.15200
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Morphea is a rare multifactorial autoimmune disorder characterized by a complex and dynamic interplay between Th1 and Th2 signaling. Active clinical trials are currently investigating the safety and efficacy of dupilumab for the treatment of primary morphea. Here, we present two cases of morphea that developed in pediatric atopic dermatitis patients treated with dupilumab. These findings may support a causal relationship between IL-4 receptor blockade and the development of the early inflammatory phase of morphea.
引用
收藏
页码：540 / 543
页数：4
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