Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies

被引：6
作者：
Silveira, Paulo Cesar Lock [1 ]
Rodrigues, Matheus Scarpatto [2 ]
Gelain, Daniel Pens [2 ]
de Oliveira, Jade [2 ]
机构：
[1] Univ Extremo Catarinense, Programa Posgrad Ciencias Saude, Criciuma, SC, Brazil
[2] Univ Fed Rio Grande Sul UFRGS, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Bioquim, Dept Bioquim, Porto Alegre, RS, Brazil
来源：
METABOLIC BRAIN DISEASE | 2023年 / 38卷 / 01期
关键词：
Nanotechnology; Nanomedicine; Gold nanoparticles; Neuroinflammation; Brain oxidative damage; Metabolic diseases; Neurodegenerative diseases; VASCULAR RISK-FACTORS; OXIDATIVE STRESS; IN-VIVO; ALZHEIMERS-DISEASE; AMYLOID-BETA; KAPPA-B; DIABETES-MELLITUS; PEEL EXTRACT; INFLAMMATION; DEMENTIA;
D O I：
10.1007/s11011-022-00929-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nanotechnology is an emerging and expanding technology worldwide. The manipulation of materials on a nanometric scale generates new products with unique properties called nanomaterials. Due to its significant expansion, nanotechnology has been applied in several fields of study, including developing materials for biomedical applications, i.e., nanomedicine. The use of nanomaterials, including nanoparticles, in nanomedicine, is promising and has been associated with pharmacokinetics, bioavailability, and therapeutic advantages. In this regard, it is worth mentioning the Gold Nanoparticles (AuNPs). AuNPs' biomedical application is extensively investigated due to their high biocompatibility, simple preparation, catalytic, and redox properties. Experimental studies have pointed out critical therapeutic actions related to AuNPs in different pathophysiological contexts, mainly due to their anti-inflammatory and antioxidant effects. Thus, in this review, we will discuss the main experimental findings related to the therapeutic properties of AuNPs in metabolic, neurodegenerative diseases, and ultimately brain dysfunctions related to metabolic diseases.
引用
收藏
页码：123 / 135
页数：13
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