Activin receptors in human cancer: Functions, mechanisms, and potential clinical applications

被引：6
作者：
Du, Ruochen [4 ,6 ]
Wen, Liqi [1 ,2 ]
Niu, Min [1 ,2 ]
Zhao, Liting [1 ,2 ]
Guan, Xiaoya [1 ,2 ]
Yang, Jiao [7 ]
Zhang, Chunming [1 ,2 ,3 ]
Liu, Hongliang [1 ,2 ,4 ,5 ]
机构：
[1] Shanxi Med Univ, Hosp 1, Shanxi Key Lab Otorhinolaryngol Head & Neck Canc, Taiyuan 030001, Shanxi, Peoples R China
[2] Shanxi Med Univ, Shanxi Prov Clin Med Res Ctr Precis Med Head & Nec, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China
[3] Shanxi Med Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Taiyuan 030001, Shanxi, Peoples R China
[4] Shanxi Med Univ, Clin Med Coll 1, Taiyuan 030001, Shanxi, Peoples R China
[5] Shanxi Med Univ, Basic Med Sch, Dept Cell Biol & Genet, Taiyuan 030001, Shanxi, Peoples R China
[6] Shanxi Med Univ, Dept Lab Anim Ctr, Taiyuan 030001, Shanxi, Peoples R China
[7] Shanxi Med Univ, Dept Anat, Basic Med Sch, Taiyuan 030001, Shanxi, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 222卷
关键词：
Activins; Activin receptor; Cancers; Functional mechanism; Clinical application; FIBROBLAST-GROWTH-FACTOR; LYMPH-NODE METASTASIS; CELL-MIGRATION; OVARIAN-CANCER; TGF-BETA; SIGNALING PATHWAY; POOR-PROGNOSIS; I RECEPTORS; TUMOR-SUPPRESSOR; ALK7; EXPRESSION;
D O I：
10.1016/j.bcp.2024.116061
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Activins are members of the transforming growth factor-13 (TGF-13) superfamily and act as key regulators in various physiological processes, such as follicle and embryonic development, as well as in multiple human diseases, including cancer. They have been established to signal through three type I and two type II serine/ threonine kinase receptors, which, upon ligand binding, form a final signal-transducing receptor complex that activates downstream signaling and governs gene expression. Recent research highlighted the dysregulation of the expression or activity of activin receptors in multiple human cancers and their critical involvement in cancer progression. Furthermore, expression levels of activin receptors have been associated with clinicopathological features and patient outcomes across different cancers. However, there is currently a paucity of comprehensive systematic reviews of activin receptors in cancer. Thus, this review aimed to consolidate existing knowledge concerning activin receptors, with a primary emphasis on their signaling cascade and emerging biological functions, regulatory mechanisms, and potential clinical applications in human cancers in order to provide novel perspectives on cancer prognosis and targeted therapy.
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页数：13
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