From gut to brain: understanding the role of microbiota in inflammatory bowel disease

被引：3

作者：

Wang, Siyu ^{[1
,2
]}

Zhou, Shuwei ^{[1
,3
]}

Han, Zhongyu ^{[1
]}

Yu, Bin ^{[2
]}

Xu, Yin ^{[2
]}

Lin, Yumeng ^{[4
]}

Chen, Yutong ^{[5
]}

Jin, Zi ^{[6
]}

Li, Yalong ^{[7
]}

Cao, Qinhan ^{[8
]}

Xu, Yunying ^{[9
]}

Zhang, Qiang ^{[2
]}

Wang, Yuan-Cheng ^{[1
,3
]}

机构：

[1] Southeast Univ, Zhongda Hosp, Sch Med, Nanjing, Peoples R China

[2] Hunan Univ Chinese Med, Dept Gastroenterol, Hosp 1, Changsha, Peoples R China

[3] Southeast Univ, Zhongda Hosp, Nurturing Ctr Jiangsu Prov State Lab AI Imaging &, Sch Med,Dept Radiol, Nanjing, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Eye Sch, Chengdu, Peoples R China

[5] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China

[6] Tongji Univ, Shanghai YangZhi Rehabil Hosp, Shanghai Sunshine Rehabil Ctr, Sch Med,Dept Anesthesiol & Pain Rehabil, Shanghai, Peoples R China

[7] Kunming Med Univ, Dept Anorectal, Affiliated Hosp 3, Kunming, Peoples R China

[8] Chengdu Univ Tradit Chinese Med TCM, Sch Clin Med, Chengdu, Peoples R China

[9] Chengdu Univ, Clin Med Sch, Affiliated Hosp, Chengdu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

inflammatory bowel disease; psychological disorders; comorbidities of mind and body; brain-gut-microbiota axis; treatment strategy; ACTIVE ULCERATIVE-COLITIS; INDUCED DEPRESSION-LIKE; CENTRAL-NERVOUS-SYSTEM; ANXIETY-LIKE BEHAVIOR; CROHNS-DISEASE; DENDRITIC CELLS; MOUSE MODEL; GASTROINTESTINAL FUNCTION; ENTEROCHROMAFFIN CELLS; INTESTINAL MICROBIOTA;

D O I：

10.3389/fimmu.2024.1384270

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the proposal of the "biological-psychological-social" model, clinical decision-makers and researchers have paid more attention to the bidirectional interactive effects between psychological factors and diseases. The brain-gut-microbiota axis, as an important pathway for communication between the brain and the gut, plays an important role in the occurrence and development of inflammatory bowel disease. This article reviews the mechanism by which psychological disorders mediate inflammatory bowel disease by affecting the brain-gut-microbiota axis. Research progress on inflammatory bowel disease causing "comorbidities of mind and body" through the microbiota-gut-brain axis is also described. In addition, to meet the needs of individualized treatment, this article describes some nontraditional and easily overlooked treatment strategies that have led to new ideas for "psychosomatic treatment".

引用

页数：17

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