From gut to brain: understanding the role of microbiota in inflammatory bowel disease

被引：3
作者：
Wang, Siyu [1 ,2 ]
Zhou, Shuwei [1 ,3 ]
Han, Zhongyu [1 ]
Yu, Bin [2 ]
Xu, Yin [2 ]
Lin, Yumeng [4 ]
Chen, Yutong [5 ]
Jin, Zi [6 ]
Li, Yalong [7 ]
Cao, Qinhan [8 ]
Xu, Yunying [9 ]
Zhang, Qiang [2 ]
Wang, Yuan-Cheng [1 ,3 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Sch Med, Nanjing, Peoples R China
[2] Hunan Univ Chinese Med, Dept Gastroenterol, Hosp 1, Changsha, Peoples R China
[3] Southeast Univ, Zhongda Hosp, Nurturing Ctr Jiangsu Prov State Lab AI Imaging &, Sch Med,Dept Radiol, Nanjing, Peoples R China
[4] Chengdu Univ Tradit Chinese Med, Eye Sch, Chengdu, Peoples R China
[5] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
[6] Tongji Univ, Shanghai YangZhi Rehabil Hosp, Shanghai Sunshine Rehabil Ctr, Sch Med,Dept Anesthesiol & Pain Rehabil, Shanghai, Peoples R China
[7] Kunming Med Univ, Dept Anorectal, Affiliated Hosp 3, Kunming, Peoples R China
[8] Chengdu Univ Tradit Chinese Med TCM, Sch Clin Med, Chengdu, Peoples R China
[9] Chengdu Univ, Clin Med Sch, Affiliated Hosp, Chengdu, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
inflammatory bowel disease; psychological disorders; comorbidities of mind and body; brain-gut-microbiota axis; treatment strategy; ACTIVE ULCERATIVE-COLITIS; INDUCED DEPRESSION-LIKE; CENTRAL-NERVOUS-SYSTEM; ANXIETY-LIKE BEHAVIOR; CROHNS-DISEASE; DENDRITIC CELLS; MOUSE MODEL; GASTROINTESTINAL FUNCTION; ENTEROCHROMAFFIN CELLS; INTESTINAL MICROBIOTA;
D O I：
10.3389/fimmu.2024.1384270
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
With the proposal of the "biological-psychological-social" model, clinical decision-makers and researchers have paid more attention to the bidirectional interactive effects between psychological factors and diseases. The brain-gut-microbiota axis, as an important pathway for communication between the brain and the gut, plays an important role in the occurrence and development of inflammatory bowel disease. This article reviews the mechanism by which psychological disorders mediate inflammatory bowel disease by affecting the brain-gut-microbiota axis. Research progress on inflammatory bowel disease causing "comorbidities of mind and body" through the microbiota-gut-brain axis is also described. In addition, to meet the needs of individualized treatment, this article describes some nontraditional and easily overlooked treatment strategies that have led to new ideas for "psychosomatic treatment".
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页数：17
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共 198 条
  • [1] Adamantidis A, 2022, SCIENCE, V376, P248, DOI 10.1126/science.abo7933
  • [2] The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications
    Allegretti, Jessica R.
    Mullish, Benjamin H.
    Kelly, Colleen
    Fischer, Monika
    [J]. LANCET, 2019, 394 (10196) : 420 - 431
  • [3] Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes
    Allen, Jacob M.
    Mackos, Amy R.
    Jaggers, Robert M.
    Brewster, Patricia C.
    Webb, Mikaela
    Lin, Chia-Hao
    Ladaika, Chris
    Davies, Ronald
    White, Peter
    Loman, Brett R.
    Bailey, Michael T.
    [J]. GUT MICROBES, 2022, 14 (01)
  • [4] Association Between Depressive Symptoms and Incidence of Crohn's Disease and Ulcerative Colitis: Results From the Nurses' Health Study
    Ananthakrishnan, Ashwin N.
    Khalili, Hamed
    Pan, An
    Higuchi, Leslie M.
    de Silva, Punyanganie
    Richter, James M.
    Fuchs, Charles S.
    Chan, Andrew T.
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (01) : 57 - 62
  • [5] The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation
    Bailey, Michael T.
    [J]. HORMONES AND BEHAVIOR, 2012, 62 (03) : 286 - 294
  • [6] Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
    Bailey, Michael T.
    Dowd, Scot E.
    Galley, Jeffrey D.
    Hufnagle, Amy R.
    Allen, Rebecca G.
    Lyte, Mark
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (03) : 397 - 407
  • [7] Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice
    Bailey, MT
    Engler, H
    Sheridan, JF
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2006, 171 (1-2) : 29 - 37
  • [8] Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations
    Bannister, Kirsty
    Patel, Ryan
    Goncalves, Leonor
    Townson, Louisa
    Dickenson, Anthony H.
    [J]. PAIN, 2015, 156 (09) : 1803 - 1811
  • [9] Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis
    Barberio, Brigida
    Zamani, Mohammad
    Black, Christopher J.
    Savarino, Edoardo, V
    Ford, Alexander C.
    [J]. LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021, 6 (05): : 359 - 370
  • [10] γ-Aminobutyric acid production by culturable bacteria from the human intestine
    Barrett, E.
    Ross, R. P.
    O'Toole, P. W.
    Fitzgerald, G. F.
    Stanton, C.
    [J]. JOURNAL OF APPLIED MICROBIOLOGY, 2012, 113 (02) : 411 - 417
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