Design of Bombyx mori (B. mori) Silk Fibroin Microspheres for Developing Biosafe Sunscreen

被引：8

作者：

Wang, Yecheng ^{[1
]}

Yang, Mei ^{[1
]}

Wang, Jie ^{[1
]}

Shuai, Yajun ^{[1
]}

Xu, Zongpu ^{[1
]}

Wan, Quan ^{[1
]}

Zhong, Suting ^{[1
]}

Mao, Chuanbin ^{[2
]}

Ping, Weidong ^{[3
]}

Yang, Mingying ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Appl Bioresource Res, Coll Anim Sci, Zhejiang Prov Key Lab Utilizat & Innovat Silkworm, Hangzhou 310058, Zhejiang, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biomed Engn, Sha Tin, Hong Kong 000000, Peoples R China

[3] Zhejiang Hosp, Dept Plast Surg, Hangzhou 310013, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 13期

基金：

中国国家自然科学基金;

关键词：

sunscreen; silk fibroin; microspheres; reactive oxygen species; biosafety; OXIDATIVE STRESS; IN-VITRO; RADICALS; PHOTOPROTECTION; PATHOGENESIS; ANTIOXIDANT; RADIATION; SILICA; HEALTH;

D O I：

10.1021/acsami.3c17879

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Sunscreens play a crucial role in protecting the skin from ultraviolet (UV) damage. However, present commercial sunscreens have a tendency to generate free radicals in the UV window, resulting in serious inflammatory responses and health problems. In this study, we demonstrate that silk fibroin microspheres (SFMPs) assembled from regenerated silk fibroin (SF) could scavenge free radicals while preventing UV irradiation and thus present a promising sunscreen. The SFMP reflected more UV light than SF and presented a higher stability than that of organic commercial sunscreens. In vitro analysis proved that SFMP could more efficiently scavenge the hydroxy radical and reduce the intracellular reactive oxygen than titanium dioxide (TiO2). In vivo experiments exhibited that SFMP provided stronger skin protection against UV irradiation than commercial sunscreens and TiO2. Furthermore, SFMP treatment significantly inhibited the skin inflammatory response. This work suggests that the SFMP has great potential to be developed into a biosafe sunscreen.

引用

页码：15798 / 15808

页数：11

共 60 条

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