Decarboxylative 1,3-dipolar cycloadditions of <sc>l</sc>-proline

被引：3

作者：

Doraghi, Fatemeh ^{[1
]}

Serajian, Azam ^{[2
]}

Karimian, Somaye ^{[3
]}

Ghanbarlou, Mehdi ^{[1
]}

Moradkhani, Fatemeh ^{[1
]}

Larijani, Bagher ^{[1
]}

Mahdavi, Mohammad ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran

[2] Inst Adv Studies Basic Sci IASBS, Dept Chem, Zanjan, Iran

[3] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran

来源：

RSC ADVANCES | 2024年 / 14卷 / 12期

关键词：

NONSTABILIZED AZOMETHINE YLIDES; BAYLIS-HILLMAN REACTION; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; OXINDOLE DERIVATIVES; DIASTEREOSELECTIVE SYNTHESIS; SPIROOXINDOLE DERIVATIVES; MOLECULAR DOCKING; FACILE SYNTHESIS;

D O I：

10.1039/d3ra08160e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,3-Dipolar cycloaddition is one of the important chemical reactions between a 1,3-dipole and a dipolarophile to construct a five-membered heterocyclic compound. As an available alpha-amino acid reactant, l-proline is extensively used in 1,3-dipolar cycloaddition reactions. A diverse spectrum of bioactive spiro and fused N-heterocycles is obtained through this synthetic approach. In this review, we have described the use of l-proline in the synthesis of various spiro- and fused heterocyclic scaffolds.

引用

页码：8481 / 8501

页数：21

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