Decarboxylative 1,3-dipolar cycloadditions of <sc>l</sc>-proline

被引：3
作者：
Doraghi, Fatemeh [1 ]
Serajian, Azam [2 ]
Karimian, Somaye [3 ]
Ghanbarlou, Mehdi [1 ]
Moradkhani, Fatemeh [1 ]
Larijani, Bagher [1 ]
Mahdavi, Mohammad [1 ]
机构：
[1] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran
[2] Inst Adv Studies Basic Sci IASBS, Dept Chem, Zanjan, Iran
[3] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran
来源：
RSC ADVANCES | 2024年 / 14卷 / 12期
关键词：
NONSTABILIZED AZOMETHINE YLIDES; BAYLIS-HILLMAN REACTION; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; OXINDOLE DERIVATIVES; DIASTEREOSELECTIVE SYNTHESIS; SPIROOXINDOLE DERIVATIVES; MOLECULAR DOCKING; FACILE SYNTHESIS;
D O I：
10.1039/d3ra08160e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
1,3-Dipolar cycloaddition is one of the important chemical reactions between a 1,3-dipole and a dipolarophile to construct a five-membered heterocyclic compound. As an available alpha-amino acid reactant, l-proline is extensively used in 1,3-dipolar cycloaddition reactions. A diverse spectrum of bioactive spiro and fused N-heterocycles is obtained through this synthetic approach. In this review, we have described the use of l-proline in the synthesis of various spiro- and fused heterocyclic scaffolds.
引用
收藏
页码：8481 / 8501
页数：21
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