Dual role of PRDX1 in redox-regulation and tumorigenesis: Past and future

被引：12
作者：
Guan, Xin [1 ]
Ruan, Yiyin [1 ]
Che, Xiaoxia [1 ]
Feng, Weiwei [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Obstet & Gynecol, Ruijin Hosp, Shanghai, Peoples R China
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2024年 / 210卷
关键词：
Peroxiredoxin 1 (PRDX1); Oxidative stress; Tumorigenesis; Chemoresistance; ROS-MEDIATED APOPTOSIS; PEROXIREDOXIN; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; 2-CYS PEROXIREDOXINS; DOWN-REGULATION; UP-REGULATION; CANCER CELLS; LUNG-CANCER; EXPRESSION;
D O I：
10.1016/j.freeradbiomed.2023.11.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour cells often display an active metabolic profile, leading to the intracellular accumulation of reactive oxygen species. As a member of the peroxidase family, peroxiredoxin 1 (PRDX1) functions generally in protecting against cell damage caused by H2O2. Additionally, PRDX1 plays a role as a molecular chaperone in various malignant tumours, exhibiting either tumour-promoting or tumour-suppressing effects. Currently, PRDX1targeting drugs have demonstrated in vitro anticancer effects, indicating the potential of PRDX1 as a molecular target. Here we discussed the diverse functions of PRDX1 in tumour biology and provided a comprehensive analysis of the therapeutic potential of targeting PRDX1 signalling across various types of cancer.
引用
收藏
页码：120 / 129
页数：10
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