Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity

被引：1
作者：
Zhang, Dong-Li [1 ]
Wang, Yue [1 ]
Liu, Jing-Bo [1 ]
Chen, Qian [1 ]
Li, Shao-Yong [1 ]
Jin, De-Jun [2 ]
Tang, Sheng-An [1 ]
机构：
[1] Tianjin Med Univ, Sch Pharm, Dev Clin Therapeut & Diag, Tianjin Key Lab Technol Enabling, Tianjin 300070, Peoples R China
[2] Hainan Med Univ, Sch Pharm, Haikou 571199, Hainan, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 217卷
关键词：
Dichapetalum longipetalum; Dichapetalaceae; Dichapetalin-type triterpenoid; RAW264.7 murine macrophages; CONSTITUENTS;
D O I：
10.1016/j.phytochem.2023.113900
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1-5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC50 value of 2.09 mu M.
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页数：6
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