Improving pore size of electrospun gelatin scaffolds containing graphene oxide using PEG as a sacrificial agent for bone tissue engineering

被引：2

作者：

Kalbali, Najmeh ^{[1
]}

Hashemi-Najafabadi, Sameereh ^{[1
]}

Bagheri, Fatemeh ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Fac Chem Engn, Biomed Engn Dept, Tehran, Iran

[2] Tarbiat Modares Univ, Fac Chem Engn, Biotechnol Dept, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 12期

关键词：

Bone tissue engineering; electrospinning; gelatin; graphene oxide; osteogenesis; polyethylene glycol; sacrificial fibers; scaffold; COMBINATION;

D O I：

10.1080/00914037.2023.2243370

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, polyethylene glycol (PEG), as a sacrificial agent, and gelatin containing graphene oxide (GO) are co-electrospun to prepare scaffolds. Based on pore size measurements, removal of PEG leads to an increase in the pore size of modified scaffolds, resulting in easier infiltration. Moreover, noticeable elastic modulus of GO increased the mechanical strength. Alizarin red staining indicated proliferation and differentiation of human bone marrow-derived mesenchymal stem cells seeded on the modified scaffolds. Thus, gelatin scaffold containing 0.5% GO with 20% PEG at the ratio of 80:20 for gelatin-PEG was selected as the optimal scaffold for bone tissue engineering approaches.

引用

页码：1068 / 1077

页数：10

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