Medication-Related Osteonecrosis: Why the Jawbone?

被引：4

作者：

Kuehn, Sydney ^{[1
]}

Scariot, Rafaela ^{[2
]}

Elsalanty, Mohammed ^{[1
]}

机构：

[1] Coll Osteopath Med Pacific, Dept Med Anat Sci, Pomona, CA 91766 USA

[2] Fed Technol Univ Parana, Dept Oral & Maxillofacial Surg, BR-80230901 Curitiba, Brazil

来源：

DENTISTRY JOURNAL | 2023年 / 11卷 / 05期

关键词：

medication-related osteonecrosis of the jaw; osteoporosis medications; osteonecrosis; BISPHOSPHONATE-RELATED OSTEONECROSIS; SURGEONS POSITION PAPER; TOOTH EXTRACTION; AMERICAN ASSOCIATION; DENTAL IMPLANTS; JAWS ONJ; BONE; DISCONTINUATION; RATS; ZOLEDRONATE;

D O I：

10.3390/dj11050109

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Medication-related osteonecrosis of the jaw (MRONJ) has emerged as a complication of anti-resorptive medications. Despite its low incidence rate, this problem has gained attention in recent years due to its devastating consequences and lack of preventive strategy. The fact that MRONJ incidence has been exclusive to the jawbones, despite the systemic effect of anti-resorptive medications, could be a starting point to unravel the multifactorial pathogenesis of this condition. This review aims to negotiate the question of why the jawbone is more susceptible to MRONJ than other skeletal sites. Approaching the problem from this perspective could provide new directions for the prevention of MRONJ and expand our understanding of the unique oral microenvironment.

引用

页数：15

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