Biological functions and potential implications of circular RNAs

被引：2

作者：

Ma, Lan ^{[1
,2
]}

Chu, Haiyan ^{[1
,2
]}

Wang, Meilin ^{[1
,2
]}

Zhang, Zhengdong ^{[1
,2
,3
]}

机构：

[1] Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Genet Toxicol,Key Lab Modern Toxicol,Minist E, Nanjing 211166, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Dept Environm Genom, Jiangsu Key Lab Canc Biomarkers Prevent & Treatmen, Nanjing 211166, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Sch Publ Hlth, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China

来源：

JOURNAL OF BIOMEDICAL RESEARCH | 2023年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

circular RNAs; biogenesis; mechanisms; database; biomarkers; COMPREHENSIVE DATABASE; MESSENGER-RNA; EXOSOMAL CIRCRNAS; CANCER-DIAGNOSIS; BREAST-CANCER; PROMOTES; TRANSLATION; BIOGENESIS; EXPRESSION; DISEASE;

D O I：

10.7555/JBR.36.20220095

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Circular RNAs (circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5 & PRIME; cap structure and 3 & PRIME; polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges, interacting with proteins, modulating the expression of related genes and translating into peptides or proteins. CircRNAs have also been used as biomarkers for a number of diseases, which could improve clinical practice. This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.

引用

页码：89 / 99

页数：11

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