Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer

被引：5
作者：
Morganti, Stefania [1 ,2 ,3 ,4 ]
Parsons, Heather A. [1 ,2 ,3 ,4 ]
Lin, Nancy U. [1 ,2 ,3 ]
Grinshpun, Albert [1 ,2 ,3 ]
机构：
[1] Dana Farber Canc Inst, Med Oncol, Boston, MA 02215 USA
[2] Dana Farber Brigham Canc Ctr, Breast Oncol Program, Boston, MA 02215 USA
[3] Harvard Med Sch, Boston, MA 02115 USA
[4] Broad Inst MIT & Harvard, Boston, MA USA
来源：
NPJ BREAST CANCER | 2023年 / 9卷 / 01期
关键词：
CIRCULATING TUMOR-CELLS; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; FREE DNA; HER2; TRASTUZUMAB; PROGRESSION; THERAPY; TOOL;
D O I：
10.1038/s41523-023-00550-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. Brain metastases pose a clinical challenge in diagnosis, treatment, and monitoring across all breast cancer subtypes, and better tools are needed. Liquid biopsy, which enables minimally invasive sampling of a patient's cancer, has the potential to shed light on intra-cranial tumor biology and to improve patient care by enabling therapy tailoring. Here we review current evidence for the clinical validity of liquid biopsy in patients with breast cancer brain metastases, with a focus on circulating tumor cells and circulating tumor DNA.
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页数：9
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