Roles of DNA damage in renal tubular epithelial cells injury

被引：9
|
作者：
Wang, Peipei [1 ,2 ,3 ]
Ouyang, Jing [1 ,2 ,3 ]
Jia, Zhanjun [1 ,2 ,3 ]
Zhang, Aihua [1 ,2 ,3 ]
Yang, Yunwen [1 ,2 ,3 ]
机构：
[1] Nanjing Med Univ, Dept Nephrol, Childrens Hosp, Nanjing, Peoples R China
[2] Nanjing Med Univ, Nanjing Key Lab Pediat, Childrens Hosp, Nanjing, Peoples R China
[3] Nanjing Med Univ, Jiangsu Key Lab Pediat, Nanjing, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
DNA damage; tubular epithelial cells; DNA repair; DDR; AKI (acute kidney injury); CKD-chronic kidney disease; CHRONIC KIDNEY-DISEASE; TRINUCLEOTIDE REPEAT MUTAGENESIS; ISCHEMIA-REPERFUSION INJURY; MITOCHONDRIAL-DNA; PERITONEAL-DIALYSIS; ENDOTHELIAL-CELLS; EXCISION-REPAIR; SEX-DIFFERENCES; RESPONSE DDR; CYCLE ARREST;
D O I：
10.3389/fphys.2023.1162546
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute kidney injury and chronic kidney disease. Reactive oxygen species (ROS) induced DNA damage is one of the most common types of DNA damage involved in the pathogenesis of acute kidney injury and chronic kidney disease. In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease. In this review, we conclude that focusing on DNA damage and DNA damage response may provide valuable diagnostic biomarkers and treatment strategies for renal diseases including acute kidney injury and chronic kidney disease.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] ENDONUCLEASE-INDUCED DNA DAMAGE AND CELL-DEATH IN OXIDANT INJURY TO RENAL TUBULAR EPITHELIAL-CELLS
    UEDA, N
    SHAH, SV
    JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (06): : 2593 - 2597
  • [2] Renal tubular epithelial cells response to injury in acute kidney injury
    Li, Zuo-Lin
    Li, Xin-Yan
    Zhou, Yan
    Wang, Bin
    Lv, Lin-Li
    Liu, Bi-Cheng
    EBIOMEDICINE, 2024, 107
  • [3] Apoptotic pathways of oxidative damage to renal tubular epithelial cells
    Basnakian, AG
    Kaushal, GP
    Shah, SV
    ANTIOXIDANTS & REDOX SIGNALING, 2002, 4 (06) : 915 - 924
  • [4] Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
    Krueger, Katharina
    Thomale, Juergen
    Stojanovic, Nikolina
    Osmak, Maja
    Henninger, Christian
    Bormann, Stefanie
    Fritz, Gerhard
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 1853 (03): : 685 - 698
  • [5] Deferiprone ameliorates cisplatin injury to renal tubular epithelial cells
    Shah, Sudhir V.
    Wang, Xiaoying
    Apostolov, Eugene O.
    Basnakian, Alexei G.
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2008, 51 (04) : A86 - A86
  • [6] DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells
    Ma, Zhengwei
    Wei, Qingqing
    Dong, Guie
    Huo, Yuqing
    Dong, Zheng
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2014, 1842 (07): : 1088 - 1096
  • [7] Zinc Oxide Nanoparticles Induce Renal Injury by Initiating Oxidative Stress, Mitochondrial Damage and Apoptosis in Renal Tubular Epithelial Cells
    Shuang Liu
    Han Zhou
    Yang Shi
    Simeng Yi
    Xinyu Wang
    Jingyan Li
    Bin Liao
    Jimin Cao
    Guang Li
    Biological Trace Element Research, 2024, 202 : 481 - 492
  • [8] Zinc Oxide Nanoparticles Induce Renal Injury by Initiating Oxidative Stress, Mitochondrial Damage and Apoptosis in Renal Tubular Epithelial Cells
    Liu, Shuang
    Zhou, Han
    Shi, Yang
    Yi, Simeng
    Wang, Xinyu
    Li, Jingyan
    Liao, Bin
    Cao, Jimin
    Li, Guang
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2024, 202 (02) : 481 - 492
  • [9] Cellular senescence of renal tubular epithelial cells in acute kidney injury
    Chen, Juan
    Zhang, Huhai
    Yi, Xiangling
    Dou, Qian
    Yang, Xin
    He, Yani
    Chen, Jia
    Chen, Kehong
    CELL DEATH DISCOVERY, 2024, 10 (01)
  • [10] Cellular senescence of renal tubular epithelial cells in acute kidney injury
    Juan Chen
    Huhai Zhang
    Xiangling Yi
    Qian Dou
    Xin Yang
    Yani He
    Jia Chen
    Kehong Chen
    Cell Death Discovery, 10
12345