Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation

被引：10

作者：

Abdel-Ghaffar, Amany ^{[1
]}

Elhossary, Ghada G. ^{[2
]}

Mahmoud, Atef M. ^{[1
]}

Elshazly, Amany H. M. ^{[2
]}

Hassanin, Olfat A. ^{[3
]}

Saleh, Anisa ^{[4
]}

Mansour, Sahar M. ^{[4
]}

Metwally, Fatma G. ^{[4
]}

Hanafy, Laila K. ^{[4
]}

Karam, Sawsan H. ^{[4
]}

Darweesh, Neveen ^{[4
]}

Ata, Ahmed Mostafa ^{[1
]}

机构：

[1] Res Inst Ophthalmol, Dept Biochem, Giza, Egypt

[2] Res Inst Ophthalmol, Dept Pharmacol, 2 Al Ahram St, Giza 12111, Egypt

[3] Res Inst Ophthalmol, Dept Ophthalmol, Giza, Egypt

[4] Res Inst Ophthalmol, Dept Histol, Giza, Egypt

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2023年 / 129卷 / 04期

关键词：

ER stress; diabetes mellitus; diabetic retinopathy; chaperones; 4-PBA;

D O I：

10.1080/13813455.2021.1888302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are good evidences suggesting that endoplasmic reticulum (ER) stress can be one of the contributing factors in the development of diabetic retinopathy. The present study was designed to investigate the effect of chemical chaperone 4-phenylbutyric acid (4-PBA) in alleviating the ER stress, and diabetic retinopathy in type 2 diabetic rats. Treatment of diabetic rats with 4-PBA, increased the antioxidant capacity, reduced the levels of lipid peroxidation, organised the state of apoptosis and regulated the ER stress - oxidative activation in retinal tissue. Also there was an improvement in the histological picture of retinal specimens compared to untreated diabetic rats. It was concluded that 4-PBA is a promising therapeutic agent for ER stress diseases such as diabetic retinopathy.

引用

页码：964 / 974

页数：11

共 59 条

[1] Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase [J].