Safety and Efficacy of Low-Dose Eptifibatide for Tandem Occlusions in Acute Ischemic Stroke

被引：2

作者：

Latacz, Pawel ^{[1
]}

Popiela, Tadeusz ^{[2
]}

Brzegowy, Pawel ^{[2
]}

Lasocha, Bartlomiej ^{[3
]}

Kwiecien, Krzysztof ^{[1
]}

Simka, Marian ^{[4
]}

机构：

[1] Bros Mercy St John God Hosp, Dept Vasc Surg & Angiol, PL-31061 Krakow, Poland

[2] Jagiellonian Univ Med Coll, Chair Radiol, PL-31008 Krakow, Poland

[3] Univ Hosp, Diagnost Imaging Unit, PL-31501 Krakow, Poland

[4] Univ Opole, Inst Med Sci, PL-45040 Opole, Poland

来源：

NEUROLOGY INTERNATIONAL | 2024年 / 16卷 / 01期

关键词：

ischemic stroke; tandem lesion; epifibatide; stent; INTERNAL CAROTID-ARTERY; INTRACRANIAL THROMBECTOMY; MANAGEMENT; THERAPY;

D O I：

10.3390/neurolint16010017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: The optimal treatment strategy for ischemic stroke in patients presenting with tandem occlusions of the internal carotid artery remains controversial. Several studies have demonstrated better clinical outcomes after eptifibatide, which is a short half-life antiplatelet agent. This retrospective analysis focused on the safety and efficacy of low-dose eptifibatide administration in stroke patients with tandem lesions. Methods: We evaluated the results of endovascular treatment in 148 stroke patients with tandem lesions. Patients in whom balloon angioplasty alone resulted in satisfactory cerebral flow did not receive eptifibatide (33 patients); others received this drug together with stent implantation (115 patients). Eptifibatide was given as an intravenous bolus of 180 mu g/kg and then in a modified low dose of 1 mu g/kg/min for 24 hours. Results: There were no statistically significant differences between both groups regarding 30-day mortality, frequency of thrombotic events, or hemorrhagic complications. An analysis of clinical status at 30-day follow-up revealed that the administration of eptifibatide was associated with a statistically significant better outcome: a higher rate of either no neurological symptoms or only mild symptoms (4 NIHSS points maximally). Conclusions: The administration of eptifibatide in stroke patients presenting with tandem lesions is relatively safe. Moreover, treatment with this drug can improve clinical outcomes in these challenging patients.

引用

页码：253 / 262

页数：10

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