A Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain

被引：2

作者：

Shen, Bin ^{[1
]}

Yoon, Daehyun ^{[2
]}

Castillo, Jessa ^{[3
]}

Biswal, Sandip ^{[4
]}

机构：

[1] Stanford Univ, Sch Med, Cyclotron Radiochem Facil, Mol Imaging Program Stanford, Stanford, CA USA

[2] Univ Calif San Francisco, Sch Med, Dept Radiol, San Francisco, CA USA

[3] Univ Calif San Francisco, Sch Med, Radiochem Facil, San Francisco, CA USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI 53706 USA

来源：

SEMINARS IN MUSCULOSKELETAL RADIOLOGY | 2023年 / 27卷 / 06期

关键词：

pain diagnosis; sigma-1; receptor; nociception; positron emission tomography; radiotracer; PRIMARY-CARE; NEUROFIBROMATOSIS TYPE-1; NEUROPATHIC PAIN; PHOSPHORYLATION; F-18-FTC-146; RADIOLIGAND; ANTAGONIST; PET/MRI; OPIOIDS; IMPACT;

D O I：

10.1055/s-0043-1775744

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from difficult-to-manage debilitating pain because of very limited diagnostic tests and a paucity of pain therapies. To help these patients, we have developed a novel clinical molecular imaging approach, and, in its early stages, it has been shown to accurately identify the exact site of pain generation using an imaging biomarker for the sigma-1 receptor and positron emission tomography/magnetic resonance imaging. We hope the description of the work in this article can help others begin their own pain imaging programs at their respective institutions.

引用

页码：601 / 617

页数：17

共 50 条

[11] Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury [J].

de la Puente, Beatriz ;

Nadal, Xavier ;

Portillo-Salido, Enrique ;

Sanchez-Arroyos, Ricard ;

Ovalle, Sergio ;

Palacios, Gabriel ;

Muro, Asuncion ;

Romero, Luz ;

Manuel Entrena, Jose ;

Manuel Baeyens, Jose ;

Antonio Lopez-Garcia, Jose ;

Maldonado, Rafael ;

Zamanillo, Daniel ;

Miguel Vela, Jose .

PAIN, 2009, 145 (03) :294-303

[12] Primary care - Low back pain [J].

Deyo, RA ;

Weinstein, JN .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (05) :363-370

[13] Opioids for Back Pain Patients: Primary Care Prescribing Patterns and Use of Services [J].

Deyo, Richard A. ;

Smith, David H. M. ;

Johnson, Eric S. ;

Donovan, Marilee ;

Tillotson, Carrie J. ;

Yang, Xiuhai ;

Petrik, Amanda F. ;

Dobscha, Steven K. .

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE, 2011, 24 (06) :717-727

[14] Schwannomatosis: a genetic and epidemiological study [J].

Evans, D. Gareth ;

Bowers, Naomi L. ;

Tobi, Simon ;

Hartley, Claire ;

Wallace, Andrew J. ;

King, Andrew T. ;

Lloyd, Simon K. W. ;

Rutherford, Scott A. ;

Hammerbeck-Ward, Charlotte ;

Pathmanaban, Omar N. ;

Freeman, Simon R. ;

Ealing, John ;

Kellett, Mark ;

Laitt, Roger ;

Thomas, Owen ;

Halliday, Dorothy ;

Ferner, Rosalie ;

Taylor, Amy ;

Duff, Chris ;

Harkness, Elaine F. ;

Smith, Miriam J. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 (11) :1215-1219

[15] Prolonged Preoperative Opioid Therapy Associated With Poor Return to Work Rates After Single-Level Cervical Fusion for Radiculopathy for Patients Receiving Workers' Compensation Benefits [J].

Faour, Mhamad ;

Anderson, Joshua T. ;

Haas, Arnold R. ;

Percy, Rick ;

Woods, Stephen T. ;

Ahn, Uri M. ;

Ahn, Nicholas U. .

SPINE, 2017, 42 (02) :E104-E110

[16] Defining the clinically important difference in pain outcome measures [J].

Farrar, JT ;

Portenoy, RK ;

Berlin, JA ;

Kinman, JL ;

Strom, BL .

PAIN, 2000, 88 (03) :287-294

[17] Physical, Cognitive, and Psychosocial Predictors of Functional Disability and Health-Related Quality of Life in Adolescents with Neurofibromatosis-1 [J].

Garwood, Molly M. ;

Bernacki, Jessica M. ;

Fine, Kathi M. ;

Hainsworth, Keri R. ;

Davies, W. Hobart ;

Klein-Tasman, Bonita P. .

PAIN RESEARCH AND TREATMENT, 2012, 2012

[18] The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats [J].

Gris, Georgia ;

Portillo-Salido, Enrique ;

Aubel, Bertrand ;

Darbaky, Yassine ;

Deseure, Kristof ;

Miguel Vela, Jose ;

Merlos, Manuel ;

Zamanillo, Daniel .

SCIENTIFIC REPORTS, 2016, 6

[19] S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice [J].

Gris, Georgia ;

Merlos, Manuel ;

Vela, Jose M. ;

Zamanillo, Daniel ;

Portillo-Salido, Enrique .

BEHAVIOURAL PHARMACOLOGY, 2014, 25 (03) :226-235

[20] Neurofibromatosis type 1 [J].

Gutmann, David H. ;

Ferner, Rosalie E. ;

Listernick, Robert H. ;

Korf, Bruce R. ;

Wolters, Pamela L. ;

Johnson, Kimberly J. .

NATURE REVIEWS DISEASE PRIMERS, 2017, 3

← 1 2 3 4 5 →