Prognostic impact of pretreatment skeletal muscle index and CONUT score in diffuse large B-cell Lymphoma

被引:10
作者
Go, Se-Il [1 ]
Choi, Bong-Hoi [2 ]
Park, Mi Jung [3 ]
Park, Sungwoo [4 ]
Kang, Myoung Hee [1 ]
Kim, Hoon-Gu [1 ]
Kang, Jung Hun [4 ]
Jeong, Eun Jeong [4 ]
Lee, Gyeong-Won [4 ]
机构
[1] Gyeongsang Natl Univ, Dept Internal Med, Div Hematol Oncol, Coll Med,y Changwon Hosp, Jinju 52727, South Korea
[2] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Nucl Med, Coll Med, Jinju, South Korea
[3] Gyeongsang Natl Univ Hosp, Coll Med, Inst Hlth Sci, Dept Radiol, Jinju, South Korea
[4] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Dept Internal Med,Div Hematol Oncol,Gyeongsang Na, Gangnam ro 79 Jinju, Jinju 52727, South Korea
关键词
Lymphoma; Diffuse large B-cell; Cachexia; Malnutrition; Sarcopenia; Controlling nutritional status; NUTRITIONAL-STATUS; ELDERLY-PATIENTS; SARCOPENIA;
D O I
10.1186/s12885-023-11590-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundAlthough the prognostic value of the Controlling Nutritional Status (CONUT) score in diffuse large B-cell lymphoma (DLBCL) has been reported in several previous studies, its clinical relevance for the presence of sarcopenia has not been assessed.MethodsIn this study, 305 DLBCL patients were reviewed. They were categorized into normal/mild (n = 219) and moderate/severe (n = 86) CONUT groups. Sarcopenia was assessed using the L3-skeletal muscle index measured by baseline computed tomography imaging. Based on CONUT score and sarcopenia, patients were grouped: A (normal/mild CONUT and no sarcopenia), B (either moderate/severe CONUT or sarcopenia, but not both), and C (both moderate/severe CONUT and sarcopenia).ResultsThe moderate/severe CONUT group showed higher rates of >= grade 3 febrile neutropenia, thrombocytopenia, non-hematologic toxicities, and early treatment discontinuation not related to disease progression, compared to the normal/mild CONUT group. The moderate/severe CONUT group had a lower complete response rate (58.1% vs. 80.8%) and shorter median overall survival (18.5 vs. 162.6 months) than the normal/mild group. Group C had the poorest prognosis with a median survival of 8.6 months, while groups A and B showed better outcomes (not reached and 60.1 months, respectively). Combining CONUT score and sarcopenia improved the predictive accuracy of the Cox regression model (C-index: 0.763), compared to the performance of using either CONUT score (C-index: 0.754) or sarcopenia alone (C-index: 0.755).ConclusionsIn conclusion, the moderate/severe CONUT group exhibited treatment intolerance, lower response, and poor prognosis. Additionally, combining CONUT score and sarcopenia enhanced predictive accuracy for survival outcomes compared to individual variables.
引用
收藏
页数:10
相关论文
共 39 条
[1]   What is the overlap between malnutrition, frailty and sarcopenia in the older population? Study protocol for cross-sectional study using UK Biobank [J].
AlMohaisen, Nada ;
Gittins, Matthew ;
Todd, Chris ;
Burden, Sorrel .
PLOS ONE, 2022, 17 (12)
[2]   Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy [J].
Camus, Vincent ;
Lanic, Helene ;
Kraut, Jerome ;
Modzelewski, Romain ;
Clatot, Florian ;
Picquenot, Jean M. ;
Contentin, Nathalie ;
Lenain, Pascal ;
Groza, Luminata ;
Lemasle, Emilie ;
Fronville, Carole ;
Cardinael, Nathalie ;
Fontoura, Marie-Laure ;
Chamseddine, Ali ;
Brehar, Oana ;
Stamatoullas, Aspasia ;
Lepretre, Stephane ;
Tilly, Herve ;
Jardin, Fabrice .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 93 (01) :9-18
[3]  
Cederholm T, 2019, CLIN NUTR, V38, P1, DOI [10.1002/jpen.1440, 10.1016/j.clnu.2018.08.002, 10.1002/jcsm.12383, 10.1016/j.clnu.2019.02.033]
[4]   Coexistence of GLIM-defined malnutrition and sarcopenia have negative effect on the clinical outcomes in the elderly gastric cancer patients after radical gastrectomy [J].
Chen, Wei-Zhe ;
Zhang, Xian-Zhong ;
Zhang, Feng-Min ;
Yu, Ding-Ye ;
Chen, Wen-Hao ;
Lin, Feng ;
Dong, Qian-Tong ;
Zhuang, Cheng-Le ;
Yu, Zhen .
FRONTIERS IN NUTRITION, 2022, 9
[5]   Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification [J].
Cheson, Bruce D. ;
Fisher, Richard I. ;
Barrington, Sally F. ;
Cavalli, Franco ;
Schwartz, Lawrence H. ;
Zucca, Emanuele ;
Lister, T. Andrew .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3059-+
[6]   CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. [J].
Coiffier, B ;
Lepage, E ;
Brière, J ;
Herbrecht, R ;
Tilly, H ;
Bouabdallah, R ;
Morel, P ;
Van den Neste, E ;
Salles, G ;
Gaulard, P ;
Reyes, F ;
Gisselbrecht, C .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (04) :235-242
[7]   TT3, a More Practical Indicator for Evaluating the Relationship Between Sarcopenia and Thyroid Hormone in the Euthyroid Elderly Compared with FT3 [Letter] [J].
Sun, Jingxia ;
Huang, Jianhao ;
Lu, Wensheng .
CLINICAL INTERVENTIONS IN AGING, 2023, 18 :1361-1362
[8]   Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update [J].
Elizabeth Jimenez-Gutierrez, Guadalupe ;
Edith Martinez-Gomez, Laura ;
Martinez-Armenta, Carlos ;
Pineda, Carlos ;
Angelica Martinez-Nava, Gabriela ;
Lopez-Reyes, Alberto .
CELLS, 2022, 11 (15)
[9]   Definition and classification of cancer cachexia: an international consensus [J].
Fearon, Kenneth ;
Strasser, Florian ;
Anker, Stefan D. ;
Bosaeus, Ingvar ;
Bruera, Eduardo ;
Fainsinger, Robin L. ;
Jatoi, Aminah ;
Loprinzi, Charles ;
MacDonald, Neil ;
Mantovani, Giovanni ;
Davis, Mellar ;
Muscaritoli, Maurizio ;
Ottery, Faith ;
Radbruch, Lukas ;
Ravasco, Paula ;
Walsh, Declan ;
Wilcock, Andrew ;
Kaasa, Stein ;
Baracos, Vickie E. .
LANCET ONCOLOGY, 2011, 12 (05) :489-495
[10]   Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer Results From the C SCANS Study [J].
Feliciano, Elizabeth M. Cespedes ;
Kroenke, Candyce H. ;
Meyerhardt, Jeffrey A. ;
Prado, Carla M. ;
Bradshaw, Patrick T. ;
Kwan, Marilyn L. ;
Xiao, Jingjie ;
Alexeeff, Stacey ;
Corley, Douglas ;
Weltzien, Erin ;
Castillo, Adrienne L. ;
Caan, Bette J. .
JAMA ONCOLOGY, 2017, 3 (12) :e172319