Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

被引：0

作者：

Gunal, Gulcin ^{[1
,2
]}

Gokcen, Dincer ^{[3
]}

Aydin, Halil Murat ^{[1
,4
]}

机构：

[1] Hacettepe Univ, Inst Sci, Bioengn Div, TR-06800 Ankara, Turkiye

[2] Akdeniz Univ, Dept Plast Surg, TR-07058 Antalya, Turkiye

[3] Hacettepe Univ, Dept Elect & Elect Engn, TR-06800 Ankara, Turkiye

[4] Hacettepe Univ, Ctr Bioengn, TR-06800 Ankara, Turkiye

来源：

ACS APPLIED BIO MATERIALS | 2023年 / 6卷 / 10期

关键词：

Cardiac patch; conductive biomaterial; multiwalledcarbon nanotubes; poly(glycerol-sebacate); extracellularmatrix;

D O I：

10.1021/acsabm.3c00557

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young's modulus of the composite elastomer were found as 5 x 10(-3) +/- 1 x 10(-3) S/m and 374 +/- 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

引用

页码：4100 / 4104

页数：5

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