Impact of time-to-surgery on survival and quality of life in oral cancer

被引：3
作者：
Tirelli, Giancarlo [1 ]
Boscolo-Rizzo, Paolo [1 ]
Pelloso, Ludovica [1 ]
Gardenal, Nicoletta [1 ]
Giudici, Fabiola [2 ]
Marcuzzo, Alberto Vito [1 ]
Tofanelli, Margherita [1 ,3 ]
机构：
[1] Univ Trieste, Dept Med Surg & Hlth Sci, Sect Otolaryngol, Trieste, Italy
[2] Univ Trieste, Dept Med Surg & Hlth Sci, Biostat Unit, Trieste, Italy
[3] Str Fiume 447, I-34129 Trieste, Italy
来源：
AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2023年 / 44卷 / 06期
关键词：
Mouth neoplasms; Squamous cell carcinoma of head and neck; Oral surgery; Time-to-treatment; Survival analysis; SQUAMOUS-CELL CARCINOMA; LOCOREGIONALLY ADVANCED HEAD; NECK-CANCER; TREATMENT DELAY; TREATMENT INITIATION; TREATMENT INTERVAL; WAITING TIME; ASSOCIATION; RADIOTHERAPY;
D O I：
10.1016/j.amjoto.2023.103984
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Purpose: To investigate the association between time-to-surgery (TTS) and overall survival (OS), disease specific survival (DSS) and quality of life (QoL) in patients with oral squamous cell carcinoma (OSCC).Materials and methods: 116 patients with OSCC candidate to surgery were examined. TTS intervals starting from diagnosis (TTS-clinical-based) and from histological reports (TTS-biopsy-based) were calculated. The effects of TTS intervals and prognostic factors on 5-year OS and DSS were explored.Results: In our cohort advanced T-categories OSCCs with TTS < 30 days showed a trend to have higher DSS rate (p = 0.049). Patients with TTS-clinical-based < 30 days showed better postoperative QoL. Positive surgical margins, nodal involvement (pN+), DOI >10 mm, invasive surgery and extra-capsular extension in pN+ were found to be significantly associated with a poor OS and DSS.Conclusions: TTS =30 days can adversely affect DSS, especially in the advanced T categories. Short TTS intervals resulted associated with a better postoperative QoL.
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页数：7
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