Paclitaxel Delivery to the Brain for Glioblastoma Treatment

被引：16

作者：

AbdEl-haq, Muhammad ^{[1
]}

Kumar, Awanish ^{[1
]}

Mohand, Fatima-ezzahra Ait ^{[2
]}

Kravchenko-Balasha, Nataly ^{[2
]}

Rottenberg, Yakir ^{[3
]}

Domb, Abraham J. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Drug Res, Fac Med, Sch Pharm, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Inst Biomed & Oral Res, Fac Dent Med, IL-91120 Jerusalem, Israel

[3] Hadassah Hebrew Univ, Med Ctr, Sharett Inst Oncol, IL-91120 Jerusalem, Israel

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 14期

关键词：

paclitaxel (PTX); poly(lactic-co-glycolic acid) (PLGA); nanoparticles (NPs); brain delivery; intranasal (IN); intravenous (IV); glioblastoma treatment; DRUG-DELIVERY; IN-VITRO; NANOPARTICLES; FORMULATION; TRANSPORT; TAXOL(R); EFFICACY; RELEASE; SYSTEM; GLIOMA;

D O I：

10.3390/ijms241411722

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague-Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

引用

页数：14

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