Peptides for trans-blood-brain barrier delivery

被引：9
作者：
Blades, Reuben [1 ]
Ittner, Lars M. [1 ]
Tietz, Ole [1 ,2 ]
机构：
[1] Macquarie Univ, Dementia Res Ctr, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW, Australia
[2] Macquarie Univ, Dementia Res Ctr, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW 2109, Australia
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2023年 / 66卷 / 09期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
blood-brain barrier; cell penetrating peptides; peptides; radiopharmaceuticals; CELL-PENETRATING PEPTIDES; ALZHEIMERS-DISEASE; THERAPEUTIC-EFFICACY; GOLD NANOPARTICLES; TARGETED DELIVERY; ANTICANCER DRUGS; SHUTTLE PEPTIDES; MOUSE MODEL; DOXORUBICIN; ANTIBODY;
D O I：
10.1002/jlcr.4023
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Trans-blood-brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. The most widely used BBB-penetrating peptides are reviewed here, with a particular emphasis on the broad range of cargos delivered into the CNS using these. Cell-penetrating peptides (CPPs) have been deployed as trans-BBB delivery agents for some time; new developments in the CPP field offer exciting opportunities for the design of next generation trans-BBB complexes. Many of the peptides highlighted here are ready to be combined with diagnostic and therapeutic radiopharmaceuticals to develop highly effective CNS-targeted agents.
引用
收藏
页码：237 / 248
页数：12
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