Cherry juice alleviates high-fat diet-induced obesity in C57BL/6J mice by resolving gut microbiota dysbiosis and regulating microRNA

被引：0
作者：
Wang, Zhen [1 ,2 ]
Liu, Hongxu [1 ,2 ]
Song, Guoku [1 ,2 ]
Gao, Jingzhu [1 ,2 ]
Xia, Xiaodong [1 ,2 ]
Qin, Ningbo [1 ,2 ]
机构：
[1] Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116304, Peoples R China
[2] Natl Engn Res Ctr Seafood, Dalian 116304, Peoples R China
来源：
FOOD & FUNCTION | 2023年 / 14卷 / 06期
基金：
中国国家自然科学基金;
关键词：
MOUSE MODEL; INFLAMMATION;
D O I：
10.1039/d2fo03023c
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cherry is a nutrient-rich food that is good for health. This study demonstrated the inhibitory action of dietary cherry juice on high-fat diet (HFD)-induced obesity in mice. Cherry juice intervention significantly decreased body weight, fat contents, and blood lipid levels in obese mice. The overproduction of proinflammatory cytokines was suppressed by dietary cherry juice, which was accompanied by the elevation of tight junction proteins to maintain intestinal barrier. Moreover, dietary cherry juice restored the decreased production of short-chain fatty acids (SCFAs) by regulating the composition and abundance of gut microbiota. In addition, dietary cherry juice also suppressed the expression of some microRNAs associated with obesity such as miR-200c-3p, miR-125a-5p, miR-132-3p, and miR-223-3p and target proteins related with microRNAs in the inguinal or epididymal white tissue in the obese mice. These results offer a fresh perspective on cherry juice's role in the prevention of obesity caused by the HFD.
引用
收藏
页码：2768 / 2780
页数：13
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