Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing

被引：3
|
作者：
Pupillo, Davide [1 ]
Zaffora, Andrea [2 ]
Di Franco, Francesco [2 ]
Picone, Pasquale [3 ,4 ]
Nuzzo, Domenico [3 ,4 ]
Santamaria, Monica [2 ]
机构：
[1] Politecn Torino, Dipartimento Sci Applicata & Tecnol, Corso Duca Abruzzi 24, I-10129 Turin, Italy
[2] Univ Palermo, Dipartimento Ingn, Viale Sci, Ed 6, I-90128 Palermo, Italy
[3] CNR, Ist Ric & Innovaz Biomed, I-90146 Palermo, Italy
[4] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut, Viale Sci, Ed 16, I-90128 Palermo, Italy
来源：
ADVANCED MATERIALS INTERFACES | 2023年 / 10卷 / 02期
关键词：
Ag; alginate; antibacterial activity; bioactivity; hydroxyapatite; Ti alloys; TITANIUM; COATINGS; SILVER; ALLOY; TI-6AL-4V; FILMS;
D O I：
10.1002/admi.202201725
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A three-step electrochemical process is developed to grow a coating on Ti6Al4V alloy for biomedical applications aimed to enhance its bioactivity. The coating is composed by a porous titanium oxide filled with Ag, alginic acid, and hydroxyapatite to provide antibacterial properties and, at the same time, osteointegration capability. Anodized and treated with the electrochemical process samples are characterized by Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDX), X-Ray Diffraction, and Raman Spectroscopy to have information about morphology and composition soon after the fabrication and after immersion in Hanks' solution. Bioactivity of the samples is also proved by electrochemical tests through Electrochemical Impedance Spectroscopy (EIS) measurements. Antibacterial properties, cytocompatibility and hemocompatibility of the samples are successfully demonstrated by in vitro tests.
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页数：12
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