Engineered Extracellular Vesicles in Chronic Kidney Diseases: A Comprehensive Review

被引：1
作者：
Xue, Kaming [1 ]
Mi, Bobin [2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷
基金：
英国科研创新办公室;
关键词：
extracellular vesicles; nanomaterials; chronic kidney diseases; drug delivery systems; application; RENAL FIBROSIS; EXOSOMES; CELLS; DELIVERY; PROGRESSION;
D O I：
10.2147/IJN.S452393
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Chronic kidney diseases (CKD) present a formidable global health challenge, characterized by a deficiency of effective treatment options. Extracellular vesicles (EVs), recognized as multifunctional drug delivery systems in biomedicine, have gained accumulative interest. Specifically, engineered EVs have emerged as a promising therapeutic approach for targeted drug delivery, potentially addressing the complexities of CKD management. In this review, we systematically dissect EVs, elucidating their classification, biogenesis, composition, and cargo molecules. Furthermore, we explore techniques for EV engineering and strategies for their precise renal delivery, focusing on cargo loading and transportation, providing a comprehensive perspective. Moreover, this review also discusses and summarizes the diverse therapeutic applications of engineered EVs in CKD, emphasizing their antiinflammatory, immunomodulatory, renoprotective, and tissue-regenerating effects. It critically evaluates the challenges and limitations in translating EV therapies from laboratory settings to clinical applications, while outlining future prospects and emerging trends.
引用
收藏
页码：2377 / 2393
页数：17
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