Asymmetric division of stem cells and its cancer relevance

被引：4
|
作者：
Chao, Shanshan [1 ,2 ,3 ]
Yan, Huiwen [1 ,2 ,3 ]
Bu, Pengcheng [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Epigenet Regulat & Intervent, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China
[3] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
来源：
CELL REGENERATION | 2024年 / 13卷 / 01期
基金：
北京市自然科学基金; 中国国家自然科学基金;
关键词：
Stem cell; Asymmetric division; Cell fate; Cancer; SARA ENDOSOMES; HISTONE INHERITANCE; SPINDLE ORIENTATION; NOTCH TRAFFICKING; SELF-RENEWAL; SEGREGATION; FATE; CENTROSOME; DNA; SWITCH;
D O I：
10.1186/s13619-024-00188-9
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Asymmetric division is a fundamental process for generating cell diversity and maintaining the stem cell population. During asymmetric division, proteins, organelles, and even RNA are distributed unequally between the two daughter cells, determining their distinct cell fates. The mechanisms orchestrating this process are extremely complex. Dysregulation of asymmetric division can potentially trigger cancer progression. Cancer stem cells, in particular, undergo asymmetric division, leading to intra-tumoral heterogeneity, which contributes to treatment refractoriness. In this review, we delve into the cellular and molecular mechanisms that govern asymmetric division and explore its relevance to tumorigenesis.
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收藏
页数：10
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