Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation

被引：0

作者：

Shiotani, Toshio ^{[1
,2
]}

Sugimoto, Seiichiro ^{[1
,2
,4
,5
]}

Tomioka, Yasuaki ^{[1
,2
]}

Tanaka, Shin ^{[1
,2
]}

Mitsuhashi, Toshiharu ^{[3
]}

Suzawa, Ken ^{[1
,2
]}

Shien, Kazuhiko ^{[1
,2
]}

Miyoshi, Kentaroh ^{[1
,2
]}

Yamamoto, Hiromasa ^{[1
,2
]}

Okazaki, Mikio ^{[1
,2
]}

Toyooka, Shinichi ^{[1
,2
]}

机构：

[1] Okayama Univ Hosp, Dept Gen Thorac Surg, Okayama, Japan

[2] Okayama Univ Hosp, Organ Transplant Ctr, Okayama, Japan

[3] Okayama Univ Hosp, Ctr Innovat Clin Med, Okayama, Japan

[4] Okayama Univ Hosp, Dept Gen Thorac Surg, 2-5-1 Shikata Cho,Kita Ku, Okayama 7008558, Japan

[5] Okayama Univ Hosp, Organ Transplant Ctr, 2-5-1 Shikata Cho,Kita Ku, Okayama 7008558, Japan

来源：

INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY | 2024年 / 38卷 / 02期

基金：

日本学术振兴会;

关键词：

Lung transplantation; Primary graft dysfunction; Histidine-rich glycoprotein; Chronic lung allograft dysfunction; Overall survival; ISHLT WORKING GROUP; INTERNATIONAL-SOCIETY; HEART; DEFINITION; STATEMENT;

D O I：

10.1093/icvts/ivae021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: Histidine-rich glycoprotein has been reported as an anti-inflammatory glycoprotein that inhibits acute lung injury in mice with sepsis and as a prognostic biomarker in patients with sepsis. We investigated the relationship between plasma concentrations of histidine-rich glycoprotein and the risk of occurrence of primary graft dysfunction. METHODS: According to the primary graft dysfunction grade at post-transplant 72 h, patients who underwent lung transplantation were divided into three groups: non-primary graft dysfunction group (grade 0-1), moderate primary graft dysfunction group (grade 2), and severe primary graft dysfunction group (grade 3). The plasma concentrations of histidine-rich glycoprotein measured daily during the first post-transplant 7 days were compared among the three groups. Appropriate cutoff values of the concentrations were set for survival analyses after lung transplantation. RESULTS: A total of 68 patients were included. The plasma histidine-rich glycoprotein concentration at post-transplant 72 h was significantly lower in the severe primary graft dysfunction group (n = 7) than in the other two groups [non-primary graft dysfunction group (n = 43), P = 0.042; moderate primary graft dysfunction group (n = 18), P = 0.040]. Patients with plasma histidine-rich glycoprotein concentration >= 34.4 mu g/ml at post-transplant 72 h had significantly better chronic lung allograft dysfunction-free survival (P = 0.012) and overall survival (P = 0.037) than those with the concentration <34.4 <mu>g/ml. CONCLUSIONS: Plasma histidine-rich glycoprotein concentrations at post-transplant 72 h might be associated with the risk of development of primary graft dysfunction.

引用

页数：8