Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions

被引：5
作者：
Costa, Barbara [1 ,2 ,3 ]
Vale, Nuno [1 ,2 ,3 ]
机构：
[1] Ctr Hlth Technol Serv Res CINTESIS, OncoPharma Res Grp, Rua Doutor Placido Costa,S-N, P-4200450 Porto, Portugal
[2] Univ Porto, Fac Med, CINTESISRISE, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal
[3] Univ Porto, Fac Med, Dept Community Med Informat & Hlth Decis Sci MEDCI, Rua Doutor Placido Costa,S-N, P-4200450 Porto, Portugal
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 19期
关键词：
human endogenous retrovirus; cancer; HERV-K (HML-2); viral infection; antiviral drugs; ENDOGENOUS-RETROVIRUS-K; ENVELOPE PROTEIN; PROSTATE-CANCER; EXPRESSION; ELEMENTS; IDENTIFICATION; CELLS; GENE; SEQUENCES; VIRUS;
D O I：
10.3390/ijms241914631
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review investigates the intricate role of human endogenous retroviruses (HERVs) in cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper sheds light on the latest research advancements and potential treatment strategies by examining the historical context of HERVs and their involvement in critical biological processes such as embryonic development, immune response, and disease progression. This review covers computational modeling for drug-target binding assessment, systems biology modeling for simulating HERV-K viral cargo dynamics, and using antiviral drugs to combat HERV-induced diseases. The findings presented in this review contribute to our understanding of HERV-mediated disease mechanisms and provide insights into future therapeutic approaches. They emphasize why HERV-K holds significant promise as a biomarker and a target.
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页数：32
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