Marital Status Is a Prognostic Factor for Cardiovascular Mortality but Not a Prognostic Factor for Cancer Mortality in Siewert Type II Adenocarcinoma of the Esophagogastric Junction

Background: The impact of marital status on the prognosis of pa-tients with Siewert type II adenocarcinoma of the esophagogatric junction (AEG) remained unclear. This study aimed to investigate the associations of marital status with cancer-specific death risk and car-diovascular death risk in Siewert type II AEG patients.Methods: Data for Siewert type II AEG patients were obtained from the Surveillance, Epidemiology, and End Results database from 2010 to 2015. A 1:1 propensity score matching (PSM) was applied to re-duce inter-group bias between the married and unmarried groups. Kaplan-Meier analysis, a competing risk model and the Fine-Gray multivariable regression model were used to identify the prognostic value of marital status.Results: In total, 1,623 subjects were included. After PSM, according to Fine-Gray multivariable regression analysis, there was no signifi-cant difference in the cumulative cancer-specific death rate between the married and the unmarried groups (hazard ratio (HR): 1.160, 95% confidence interval (CI): 0.994 -1.354, P = 0.060). Patients in unmar-ried group had a higher cardiovascular death rate than patients in mar-ried group (HR: 3.066, 95% CI: 1.372 -6.850, P = 0.006). Conclusions: Our study demonstrates that unmarried Siewert type II AEG patients are associated with higher cardiovascular death risk but not cancer-specific death risk compared with married patients.