Ir-catalyzed asymmetric hydrogenation of 2-Aryl-3H-indoles with chiral phosphine-phosphoramidite ligands

被引：1

作者：

Cao, Haiyan ^{[1
]}

Zhou, Mingdong ^{[1
]}

Yin, Hang ^{[1
]}

Zheng, Kaikai ^{[1
]}

Zhang, Zheng ^{[1
]}

Shuai, Qiucen ^{[1
]}

Guan, Ruitong ^{[1
]}

Wang, Kangjun ^{[1
]}

Yang, Ying ^{[1
]}

Guan, Jin ^{[1
]}

Hu, Xinhu ^{[1
]}

机构：

[1] Shenyang Univ Chem Technol, Coll Chem Engn, Shenyang 110142, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2024年 / 1004卷

关键词：

Hydrogenation; Asymmetric catalysis; Iridium; 2-Aryl-3H-indoles; Chiral phosphine-phosphoramidite ligand; HIGHLY ENANTIOSELECTIVE SYNTHESIS; KINETIC RESOLUTION; INDOLINES; INDOLES; ACID; DEAROMATIZATION; ALKYLATION; DIVERSITY; COMPLEXES; SCAFFOLDS;

D O I：

10.1016/j.jorganchem.2023.122953

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An asymmetric synthesis of indolines has been described by using an Ir-catalyzed asymmetric hydrogenation of 2-aryl-3H-indoles with unsymmetrical hybrid chiral phosphine-phosphoramidite ligands. The result indicated that the catalytic performance could be significantly improved by the H8-binaphthyl moiety on this ligand motif. This method is characterized by a high asymmetric induction and a reasonable functional group tolerance, thus providing a concise and efficient approach toward chiral indoline and their derivatives with up to 94 % ee.

引用

页数：5

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