Two new isostructural lanthanide metal-organic frameworks based on 2,5-furandicarboxylic acid for highly efficient sensing of lysophosphatidic acid

Ovarian cancer (OC) is a serious health concern that is highly prevailing in women. In this regard, lysophosphatidic acid (LPA) is used as a biomarker for OC, and hence its early detection can help in a better treatment plan and cure of the disease. Thus, two new lanthanide metal-organic frameworks [Eu2(FDA)3(DMF)2(MeOH)2]n (Eu-MOF) and [Tb2(FDA)3(DMF)2(MeOH)2]n (Tb-MOF) were synthesized by using 2,5-furandicarboxylic acid as ligand under solvothermal method, which were in turn applied for the detection of LPA. Single-crystal X-ray diffraction indicated that both the Eu-MOF and Tb-MOF were isomorphic with tfz-d topology of {43}2{46.618.84} based on binuclear second building units to form 3D framework. Meanwhile, Eu-MOF realized highly selective detection for LPA through a strong fluorescence quenching with KSV = 1.17 x 104 M-1, effectively identified LPA compared to other major components of plasma. These findings conclude that Eu-MOF can be counted as a potential contender as a fluorescent sensor for the detection of LPA which can in turn help the early diagnosis of OC.