Left ventricular remodeling and its correlates among adolescents with perinatally acquired HIV in South Africa

被引：5

作者：

Magodoro, Itai M. ^{[1
,2
]}

Guerrero-Chalela, Carlos E. ^{[3
]}

Claggett, Brian ^{[4
,5
]}

Jermy, Stephen ^{[6
]}

Samuels, Petronella ^{[6
]}

Zar, Heather ^{[7
,8
,9
]}

Myer, Landon ^{[10
]}

Danaei, Goodarz ^{[11
,12
]}

Jao, Jennifer ^{[13
,14
]}

Ntusi, Ntobeko A. B. ^{[6
,9
,15
,16
]}

Siedner, Mark J. ^{[5
,17
,18
]}

Ntsekhe, Mpiko ^{[1
]}

机构：

[1] Univ Cape Town, Div Cardiol, Cape Town, South Africa

[2] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA USA

[3] Fdn Cardioinfantil Inst Cardiol, Bogota, Colombia

[4] Brigham & Womens Hosp, Cardiol Div, Boston, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Univ Cape Town, Cape Univ Body Imaging Ctr, Cape Town, South Africa

[7] Univ Cape Town, Dept Pediat & Child Hlth, Cape Town, South Africa

[8] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Cape Town, South Africa

[9] Univ Cape Town, Dept Med, Cape Town, South Africa

[10] Univ Cape Town, Sch Publ Hlth & Family Med, Cape Town, South Africa

[11] Harvard Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA

[12] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[13] Northwestern Univ, Dept Pediat, Div Pediat Infect Dis, Feinberg Sch Med, Chicago, IL USA

[14] Northwestern Univ, Dept Internal Med, Div Adult Infect Dis, Feinberg Sch Med, Chicago, IL USA

[15] Univ Cape Town, Cape Heart Inst, Cape Town, South Africa

[16] South African Med Res Council Extramural Unit Non, Cape Town, South Africa

[17] Massachusetts Gen Hosp, Boston, MA USA

[18] Africa Hlth Res Inst, Kwa Zulu, South Africa

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2023年 / 387卷

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

PHIV; Cardiac remodeling; Adolescence; South Africa; ANTIRETROVIRAL THERAPY; EJECTION FRACTION; GEOMETRY; DISEASE; HEART; INFECTION; CHILDREN; RISK; MASS;

D O I：

10.1016/j.ijcard.2023.131121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Left ventricular (LV) remodeling and its transitions from compensatory adaptations to LV dysfunction have not been examined in adolescents with perinatally acquired HIV infection (PHIV). We used cardiovascular magnetic resonance (CMR) in a cross-sectional study to characterize PHIV-related progressive LV remodeling in adolescents in South Africa. Methods: Adolescents with PHIV on antiretroviral treatment and their HIV uninfected peers completed 3 T CMR examination. We defined LV remodeling by LV mass/volume (M/V) ratio, modelling progressive LV remodeling as increasing M/V ratio. Linear regression models were applied to estimate the correlates of progressive LV remodeling. Results: Overall, 71 adolescents with PHIV [mean age: 15.2 years; 54% male] and 36 HIV uninfected [15.1 years; 42% male] peers were enrolled. Adolescents with PHIV had lower mean LV M/V ratio (0.68 vs. 0.75 g/mL; p = 0.004) than HIV uninfected peers, without LV hypertrophy in either group. Among adolescents with PHIV, increasing M/V ratio was accompanied by increasing interstitial volume [adjusted mean change (AMC) per 0.1 g/mL M/V ratio: 1.75 mL, p < 0.001] with no change in global circumferential strain (GCS) [AMC per 0.1 g/mL M/V ratio:-0.21%, p = 0.48]. However, in HIV uninfected individuals, increasing M/V ratio was accompanied by increasing peak GCS [AMC per 0.1 g/mL M/V ratio:-1.25%, p = 0.039] with no change in interstitial volume (AMC per 0.1 g/mL M/V ratio: 1.16 mL, p = 0.32]. Conclusions: Successfully treated PHIV is associated with less severe LV remodeling in adolescence when compared to HIV uninfected controls. LV remodeling in PHIV is associated with disproportionate expansion of the non-contractile interstitium not accompanied by improved GCS.

引用

页数：7