Left ventricular remodeling and its correlates among adolescents with perinatally acquired HIV in South Africa

被引:5
作者
Magodoro, Itai M. [1 ,2 ]
Guerrero-Chalela, Carlos E. [3 ]
Claggett, Brian [4 ,5 ]
Jermy, Stephen [6 ]
Samuels, Petronella [6 ]
Zar, Heather [7 ,8 ,9 ]
Myer, Landon [10 ]
Danaei, Goodarz [11 ,12 ]
Jao, Jennifer [13 ,14 ]
Ntusi, Ntobeko A. B. [6 ,9 ,15 ,16 ]
Siedner, Mark J. [5 ,17 ,18 ]
Ntsekhe, Mpiko [1 ]
机构
[1] Univ Cape Town, Div Cardiol, Cape Town, South Africa
[2] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA USA
[3] Fdn Cardioinfantil Inst Cardiol, Bogota, Colombia
[4] Brigham & Womens Hosp, Cardiol Div, Boston, MA USA
[5] Harvard Med Sch, Boston, MA USA
[6] Univ Cape Town, Cape Univ Body Imaging Ctr, Cape Town, South Africa
[7] Univ Cape Town, Dept Pediat & Child Hlth, Cape Town, South Africa
[8] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Cape Town, South Africa
[9] Univ Cape Town, Dept Med, Cape Town, South Africa
[10] Univ Cape Town, Sch Publ Hlth & Family Med, Cape Town, South Africa
[11] Harvard Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA
[12] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[13] Northwestern Univ, Dept Pediat, Div Pediat Infect Dis, Feinberg Sch Med, Chicago, IL USA
[14] Northwestern Univ, Dept Internal Med, Div Adult Infect Dis, Feinberg Sch Med, Chicago, IL USA
[15] Univ Cape Town, Cape Heart Inst, Cape Town, South Africa
[16] South African Med Res Council Extramural Unit Non, Cape Town, South Africa
[17] Massachusetts Gen Hosp, Boston, MA USA
[18] Africa Hlth Res Inst, Kwa Zulu, South Africa
基金
美国国家卫生研究院; 英国医学研究理事会;
关键词
PHIV; Cardiac remodeling; Adolescence; South Africa; ANTIRETROVIRAL THERAPY; EJECTION FRACTION; GEOMETRY; DISEASE; HEART; INFECTION; CHILDREN; RISK; MASS;
D O I
10.1016/j.ijcard.2023.131121
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Left ventricular (LV) remodeling and its transitions from compensatory adaptations to LV dysfunction have not been examined in adolescents with perinatally acquired HIV infection (PHIV). We used cardiovascular magnetic resonance (CMR) in a cross-sectional study to characterize PHIV-related progressive LV remodeling in adolescents in South Africa. Methods: Adolescents with PHIV on antiretroviral treatment and their HIV uninfected peers completed 3 T CMR examination. We defined LV remodeling by LV mass/volume (M/V) ratio, modelling progressive LV remodeling as increasing M/V ratio. Linear regression models were applied to estimate the correlates of progressive LV remodeling. Results: Overall, 71 adolescents with PHIV [mean age: 15.2 years; 54% male] and 36 HIV uninfected [15.1 years; 42% male] peers were enrolled. Adolescents with PHIV had lower mean LV M/V ratio (0.68 vs. 0.75 g/mL; p = 0.004) than HIV uninfected peers, without LV hypertrophy in either group. Among adolescents with PHIV, increasing M/V ratio was accompanied by increasing interstitial volume [adjusted mean change (AMC) per 0.1 g/mL M/V ratio: 1.75 mL, p < 0.001] with no change in global circumferential strain (GCS) [AMC per 0.1 g/mL M/V ratio:-0.21%, p = 0.48]. However, in HIV uninfected individuals, increasing M/V ratio was accompanied by increasing peak GCS [AMC per 0.1 g/mL M/V ratio:-1.25%, p = 0.039] with no change in interstitial volume (AMC per 0.1 g/mL M/V ratio: 1.16 mL, p = 0.32]. Conclusions: Successfully treated PHIV is associated with less severe LV remodeling in adolescence when compared to HIV uninfected controls. LV remodeling in PHIV is associated with disproportionate expansion of the non-contractile interstitium not accompanied by improved GCS.
引用
收藏
页数:7
相关论文
共 50 条
  • [31] Prevalence and Predictors of Drug Use Among Adolescents with HIV Infection Acquired Perinatally or Later in Life
    Conner, Latoya C.
    Wiener, Jeffrey
    Lewis, Jennifer V.
    Phill, Rhonda
    Peralta, Ligia
    Chandwani, Sulachni
    Koenig, Linda J.
    AIDS AND BEHAVIOR, 2013, 17 (03) : 976 - 986
  • [32] Traditional and biomedical health practices of adolescent boys and young men living with perinatally-acquired HIV in the Eastern Cape Province of South Africa
    Gittings, Lesley
    Colvin, Christopher
    Hodes, Rebecca
    GLOBAL PUBLIC HEALTH, 2023, 18 (01)
  • [33] Differing psychological vulnerabilities among behaviourally and perinatally HIV infected adolescents in South Africa - implications for targeted health service provision
    Sherr, L.
    Cluver, L. D.
    Toska, E.
    He, E.
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2018, 30 : 92 - 101
  • [34] Combination Social Protection for Reducing HIV-Risk Behavior Among Adolescents in South Africa
    Cluver, Lucie D.
    Orkin, F. Mark
    Yakubovich, Alexa R.
    Sherr, Lorraine
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2016, 72 (01) : 96 - 104
  • [35] Views of adolescents living with perinatally acquired HIV on HIV status disclosure in Eswatini
    Dlamini, Baliwe P.
    Mtshali, Ntombifikile G.
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2024, 36 (09): : 1263 - 1271
  • [36] ‘If I am playing football, I forget that I have this virus’: the challenges and coping strategies of adolescents with perinatally acquired HIV in KwaZulu-Natal, South Africa
    Marian Loveday
    Jennifer Furin
    Sindisiwe Hlangu
    Thabile Mthethwa
    Tasneem Naidoo
    BMC Infectious Diseases, 22
  • [37] Correlates of HIV Testing Among Abused Women in South Africa
    Adams, Julie L.
    Hansen, Nathan B.
    Fox, Ashley M.
    Taylor, Baishakhi B.
    van Rensburg, Madri Jansen
    Mohlahlane, Rakgadi
    Sikkema, Kathleen J.
    VIOLENCE AGAINST WOMEN, 2011, 17 (08) : 1014 - 1023
  • [38] "When Should I Tell?": Perspectives on Disclosure to Their Children among Parents with Perinatally Acquired HIV
    Fair, Cynthia D.
    Allen, Hannah
    Trexler, Constance
    Osherow, Janet
    D'Angelo, Lawrence
    FRONTIERS IN PUBLIC HEALTH, 2016, 4
  • [39] HIV-Related Stigma and Psychological Adjustment Among Perinatally HIV-Infected Youth in Cape Town, South Africa
    Perez, Alexander
    Brittain, Kirsty
    Phillips, Nicole
    Stein, Dan J.
    Zar, Heather J.
    Myer, Landon
    Hoare, Jacqueline
    AIDS AND BEHAVIOR, 2022, 26 (02) : 434 - 442
  • [40] HIV and Hepatitis B Coinfection Among Perinatally HIV-infected Thai Adolescents
    Aurpibul, Linda
    Lumbiganon, Pagakrong
    Kosalaraksa, Pope
    Hansudewechakul, Rawiwan
    Sa-nguanmoo, Pattaratida
    Taeprasert, Pawinee
    Bunupuradah, Torsak
    Poovorawan, Yong
    Sirisanthana, Virat
    Puthanakit, Thanyawee
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2012, 31 (09) : 943 - 947