Clinical impact of minimal residual disease in blood and bone marrow of children with acute myeloid leukemia

被引：6

作者：

Karol, Seth E. ^{[1
]}

Coustan-Smith, Elaine ^{[2
]}

Pounds, Stanley ^{[3
]}

Wang, Lei ^{[3
]}

Inaba, Hiroto ^{[1
]}

Ribeiro, Raul C. ^{[1
]}

Pui, Ching-Hon ^{[1
]}

Klco, Jeffery M. ^{[4
]}

Rubnitz, Jeffrey E. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[2] Natl Univ Hlth Syst, Dept Pediat, Singapore, Singapore

[3] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN USA

来源：

BLOOD ADVANCES | 2023年 / 7卷 / 14期

基金：

美国国家卫生研究院;

关键词：

FLOW-CYTOMETRY; THERAPY; CLEARANCE; MRD;

D O I：

10.1182/bloodadvances.2022009534

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic significance of bone marrow minimal residual disease (MRD) in pediatric patients with acute myeloid leukemia (AML) is well characterized, but the impact of blood MRD is not known. We, therefore, used flow cytometric assessment of leukemia-specific immunophenotypes to measure levels of MRD in both the blood and bone marrow of patients treated in the AML08 (NCT00703820) clinical trial. Blood samples were obtained on days 8 and 22 of therapy, whereas bone marrow samples were obtained on day 22. Among patients who tested as having MRD-negative bone marrow on day 22, neither day-8 nor day-22 blood MRD was significantly associated with the outcome. However, day-8 blood MRD was highly predictive of the outcome among patients who tested as having MRD-positive bone marrow on day 22. Although the measurement of blood MRD on day 8 cannot be used to identify patients who have day-22 MRD-negative bone marrow who are likely to relapse, our findings suggest that day-8 blood MRD results can identify patients with MRD-positive bone marrow who have a dismal prognosis and may be candidates for the early use of experimental therapy.

引用

页码：3651 / 3657

页数：7

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