miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

被引：44

作者：

El-Mahdy, Hesham A. ^{[1
]}

Mohamadin, Ahmed M. ^{[1
]}

Abulsoud, Ahmed I. ^{[1
,2
]}

Khidr, Emad Gamil ^{[1
]}

El-Husseiny, Ahmed A. ^{[1
,3
]}

Ismail, Ahmed ^{[1
]}

Elsakka, Elsayed G. E. ^{[1
]}

Mokhlis, Hamada Ahmed ^{[4
]}

El-Husseiny, Hussein M. ^{[5
,6
]}

Doghish, Ahmed S. ^{[7
,8
]}

机构：

[1] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt

[2] Heliopolis Univ, Fac Pharm, Dept Biochem & Biotechnol, Cairo 11785, Egypt

[3] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[4] Al Azhar Univ, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11231, Egypt

[5] Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan

[6] Benha Univ, Fac Vet Med, Dept Surg Anesthesiol & Radiol, Toukh 13736, Al Qalyubia, Egypt

[7] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[8] Al Azhar Univ, Fac Pharm Boys, Cairo 11231, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 245卷

关键词：

HNCs; Tumor suppressor miR; Oncogenic miR; Pathogenesis; Drug resistance; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; NASOPHARYNGEAL CARCINOMA; CISPLATIN-RESISTANCE; TUMOR-SUPPRESSOR; DOWN-REGULATION; TGF-BETA; POOR-PROGNOSIS; CIRCULATING MICRORNAS; MULTIDRUG-RESISTANCE;

D O I：

10.1016/j.prp.2023.154457

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth. Numerous epigenetic components, including miRNAs, have been demonstrated to have an impact on HNCs characteristics like progression, angiogenesis, initiation, and resistance to therapeutic interventions. The miRNAs may control the production of numerous genes linked to HNCs pathogenesis. The roles that miRNAs play in angiogenesis, invasion, metastasis, cell cycle, proliferation, and apoptosis are responsible for this impact. The miRNAs also have an impact on crucial HNCs-related mechanistic networks like the WNT/ll-catenin signaling, PTEN/Akt/mTOR pathway, TGFll, and KRAS mutations. miRNAs may affect how the HNCs respond to treatments like radiation and chemotherapy in addition to pathophysiology. This review aims to demonstrate the relationship between miRNAs and HNCs with a particular emphasis on how miRNAs impact HNCs signaling networks.

引用

页数：17

共 283 条

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