Complementary charge-driven encapsulation of functional protein by engineered protein cages in cellulo

被引：1

作者：

Zakaszewski, Daniel ^{[1
,2
]}

Koziej, Lukasz ^{[1
]}

Pankowski, Jedrzej ^{[1
,3
]}

Malolan, V. Vishal ^{[1
,2
]}

Gamperli, Nina ^{[4
]}

Heddle, Jonathan G. G. ^{[1
]}

Hilvert, Donald ^{[4
]}

Azuma, Yusuke ^{[1
,4
]}

机构：

[1] Jagiellonian Univ, Malopolska Ctr Biotechnol MCB, Gronostajowa 7A, PL-30387 Krakow, Poland

[2] Jagiellonian Univ, Doctoral Sch Exact & Nat Sci, Prof S Lojasiewicza 11, PL-30348 Krakow, Poland

[3] Jagiellonian Univ, Fac Biochem, Biophys, Sand Biotechnol, Gronostajowa 7, PL-30387 Krakow, Poland

[4] Swiss Fed Inst Technol, Lab Organ Chem, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2023年 / 11卷 / 28期

关键词：

EVOLUTION; CARGO; FERRITIN; MICROCOMPARTMENT; MECHANISM; PROTEASES; ENZYMES;

D O I：

10.1039/d3tb00754e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Charge-driven inclusion complex formation in live cells was examined using a degradation-prone fluorescent protein and a series of protein cages. The results show that sufficiently strong host-guest ionic interaction and an intact shell-like structure are crucial for the protective guest encapsulation.

引用

页码：6540 / 6546

页数：7

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