Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging

被引：61

作者：

Wei, Ruwei ^{[1
]}

Dong, Yan ^{[1
]}

Wang, Xueli ^{[2
]}

Li, Jin ^{[1
]}

Lei, Zuhai ^{[3
]}

Hu, Zhubin ^{[2
]}

Chen, Jinquan ^{[2
]}

Sun, Haitao ^{[2
]}

Chen, Hao ^{[4
]}

Luo, Xiao ^{[5
]}

Qian, Xuhong ^{[1
,5
]}

Yang, Youjun ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[2] East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Dongchuan Rd 500, Shanghai 200241, Peoples R China

[3] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Zhangheng Rd 826, Shanghai 201203, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China

[5] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Sch Chem & Mol Engn, Dongchuan Rd 500, Shanghai 200241, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2023年 / 145卷 / 22期

基金：

中国国家自然科学基金;

关键词：

HEPTAMETHINE CYANINE DYES; BILE-DUCT INJURY; INDOCYANINE-GREEN; LAPAROSCOPIC CHOLECYSTECTOMY; ORGANIC FLUOROPHORES; SYMMETRY-BREAKING; BRIGHT; RHODAMINE; WAVELENGTH; DESIGN;

D O I：

10.1021/jacs.3c00594

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The shortwave infrared (SWIR) spectral region beyond1200 nm offersoptimal tissue penetration depth and has broad potential in diagnosis,therapy, and surgery. Here, we devised a novel class of fluorochromicscaffold, i.e., a tetra-benzannulated xanthenoid (EC7). EC7 absorbs/emits maximally at 1204/1290 nm in CH2Cl2 and exhibits an unparalleled molar absorptivityof 3.91 x 10(5) cm(-1) M-1 and high transparency to light at 400-900 nm. It also exhibitedhigh resistance toward both photobleaching and symmetry breaking dueto its unique structural rigidity. It is feasible for in vivo bioimagingand particularly suitable to couple with the shorter-wavelength analoguesfor high-contrast multiplexing. High-contrast dual-channel intraoperativeimaging of the hepatobiliary system and three-channel in vivo imagingof the intestine, the stomach, and the vasculature were showcased. EC7 is a benchmark fluorochrome for facile biomedical exploitationof the SWIR region beyond 1200 nm.

引用

页码：12013 / 12022

页数：10

共 70 条

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