CFTR High Expresser Cells in cystic fibrosis and intestinal diseases

被引：5

作者：

dos Reis, Diego Carlos ^{[1
]}

Dastoor, Parinaz ^{[1
]}

Santos, Anderson Kenedy ^{[1
,2
]}

Sumigray, Kaelyn ^{[2
,3
,4
]}

Ameen, Nadia A. ^{[1
,5
]}

机构：

[1] Yale Sch Med, Dept Pediat Gastroenterol & Hepatol, New Haven, CT 06510 USA

[2] Yale Sch Med, Dept Genet, New Haven, CT 06510 USA

[3] Yale Sch Med, Yale Stem Cell Ctr, New Haven, CT 06510 USA

[4] Yale Sch Med, Yale Canc Ctr, New Haven, CT 06510 USA

[5] Yale Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

HELIYON | 2023年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CFTR; Cystic fibrosis; CFTR high expresser cells; Intestinal disease; Ionocytes; Mitochondria rich cells; TRANSMEMBRANE CONDUCTANCE REGULATOR; MICROVILLUS INCLUSION DISEASE; TRANSCRIPTION FACTOR FOXI1; MESSENGER-RNA EXPRESSION; MITOCHONDRIA-RICH CELLS; GUANYLYL CYCLASE-C; CELLULAR-LOCALIZATION; SECRETORY-CELL; ION-TRANSPORT; OREOCHROMIS-MOSSAMBICUS;

D O I：

10.1016/j.heliyon.2023.e14568

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl-/HCO3- channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many gastrointestinal diseases. Defects in CFTR lead to intestinal dysfunction, malabsorption, obstruction, infection, inflammation, and cancer that increases morbidity and reduces quality of life. This review will focus on CFTR in the intestine and the implications of the subpopulation of CFTR High Expresser Cells (CHEs) in Cystic Fibrosis (CF), intestinal physiology and pathophysiology of intestinal diseases.

引用

页数：12

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