Noncoding RNAs and Cardiac Fibrosis

被引：1

作者：

Wu, Changyong ^{[1
]}

Bao, Suli ^{[1
]}

Li, Ruijie ^{[1
]}

Sun, Huang ^{[1
]}

Peng, Yunzhu ^{[1
]}

机构：

[1] Kunming Med Univ, Dept Cardiol, Affiliated Hosp 1, Kunming 650000, Yunnan, Peoples R China

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2023年 / 24卷 / 02期

关键词：

non-coding RNAs; myocardial fibrosis; biomarker; gene regulation; molecular mechanism; MYOCARDIAL FIBROSIS; CIRCULAR RNA; ATRIAL-FIBRILLATION; RATS; DYSFUNCTION; INJURY;

D O I：

10.31083/j.rcm2402063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive fibrosis is the pathological basis for the development and progression of many cardiac arrhythmias and heart failure. There are no effective reversal drugs for myocardial fibrosis due to the lack of understanding of the molecular mechanisms. Noncoding RNAs, a class of RNAs that do not function in coding proteins, have been found to be intimately involved in the life cycle of cardiomyocyte differentiation, transcription and apoptosis and are important regulators of cardiovascular disease. An increasing number of studies have shown that noncoding RNAs regulate the proliferation and transformation of cardiac fibroblasts through related signaling pathways and can be used as potential biomarkers and novel therapeutic targets for cardiac fibrosis. This article reviews the relationship between noncoding RNAs and cardiac fibrosis.

引用

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