Emerging roles of tRNA-derived fragments in cancer

被引：51

作者：

Fu, Min ^{[1
,2
]}

Gu, Jianmei ^{[3
]}

Wang, Maoye ^{[2
]}

Zhang, Jiahui ^{[2
]}

Chen, Yanke ^{[2
]}

Jiang, Pengcheng ^{[1
]}

Zhu, Taofeng ^{[4
]}

Zhang, Xu ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Peoples Hosp, Inst Digest Dis, Zhenjiang 212002, Jiangsu, Peoples R China

[2] Jiangsu Univ, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, Zhenjiang 212013, Jiangsu, Peoples R China

[3] Nantong Univ, Nantong Tumor Hosp, Tumor Hosp, Dept Clin Lab Med, Nantong 226361, Jiangsu, Peoples R China

[4] Jiangsu Univ, Yixing Hosp, Dept Pulm & Crit Care Med, Yixing 214200, Jiangsu, Peoples R China

来源：

MOLECULAR CANCER | 2023年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

tRNA-derived fragments; tRNA halves; Cancer; Biomarker; PROMOTES CELL-PROLIFERATION; SMALL NONCODING RNAS; EXTRACELLULAR VESICLES; DIAGNOSTIC BIOMARKERS; RIBONUCLEIC-ACID; BREAST; STRESS; IDENTIFICATION; EXPRESSION; NUCLEAR;

D O I：

10.1186/s12943-023-01739-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physiological and pathophysiological processes. tRFs can regulate cell viability, differentiation, and homeostasis through multiple mechanisms and are thus considered as critical regulators of human diseases including cancer. In addition, increasing evidence suggest the extracellular tRFs may be utilized as promising diagnostic and prognostic biomarkers for cancer liquid biopsy. In this review, we focus on the biogenesis, classification and modification of tRFs, and summarize the multifaceted functions of tRFs with an emphasis on the current research status and perspectives of tRFs in cancer.

引用

页数：27

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