Radiation-assisted strategies provide new perspectives to improve the nanoparticle delivery to tumor

被引：7
|
作者：
Zhang, Dongxiao [1 ,2 ,3 ]
He, Jian [3 ]
Zhou, Min [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 4, Dept Resp & Crit Care Med, Sch Med, Yiwu 322000, Peoples R China
[2] Zhejiang Univ, Univ Edinburgh Inst, Sch Med, ZJU UoE Inst, Haining 314400, Peoples R China
[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Peoples R China
[4] Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China
[5] Zhejiang Univ, Res Ctr Life Sci & Human Hlth, Binjiang Inst, Hangzhou 310053, Peoples R China
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2023年 / 193卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Nanoparticle; Drug delivery; Radiotherapy pretreatment; Tumor distribution; Cancer therapy; INTERSTITIAL FLUID PRESSURE; WALKER CARCINOMA 256; DRUG-DELIVERY; LIPOSOMAL DOXORUBICIN; VASCULAR-PERMEABILITY; PHOTODYNAMIC THERAPY; CANCER-CELLS; DNA-DAMAGE; BLOOD-FLOW; MICROENVIRONMENT;
D O I：
10.1016/j.addr.2022.114642
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanoparticles (NPs), with advantages in tumor targeting, have been extensively developed for anticancer treatment. However, the delivery efficacy of NPs tends to be heterogeneous in clinical research. Surprisingly, a traditional cancer treatment, radiotherapy (radiation), has been observed with the potential to improve the delivery of NPs by influencing the features of the tumor microenvironment, which provides new perspectives to overcome the barriers in the NPs delivery. Since the effect of radiation can also be enhanced by versatile NPs, these findings of radiation-assisted NPs delivery suggest innovative strategies combining radiotherapy with nanotherapeutics. This review summarizes the research on the delivery and therapeutic efficacy of NPs that are improved by radiation, focusing on relative mechanisms and existing challenges and opportunities.(c) 2022 Elsevier B.V. All rights reserved.
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页数：13
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