Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance

被引：5
作者：
Milano, C. [1 ]
Montali, M. [2 ]
Barachini, S. [2 ]
Burzi, I. S. [2 ]
Pratesi, F. [3 ]
Petrozzi, L. [1 ]
Chico, L. [1 ]
Morganti, R. [4 ]
Gambino, G. [2 ]
Rossi, L. [2 ]
Ceravolo, R. [1 ]
Siciliano, G. [1 ]
Migliorini, P. [5 ]
Petrini, I. [3 ]
Pizzanelli, C. [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, Neurol Unit, Pisa, Italy
[2] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
[3] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy
[4] Univ Pisa, Sect Stat, Pisa, Italy
[5] Univ Pisa, Dept Clin & Expt Med, Clin Immunol & Allergy Unit, Pisa, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2024年 / 386卷
关键词：
Drug-resistant epilepsy; Mesial temporal lobe epilepsy; Neuroinflammation; Oxidative stress; Peripheral blood mononuclear cells; Cytokines; OXIDATIVE STRESS MARKERS; CHEMOATTRACTANT PROTEIN-1; STATUS EPILEPTICUS; ADAPTIVE IMMUNITY; RAT MODEL; IL-1-BETA; CHILDREN; SEIZURES; ILAE; EPILEPTOGENESIS;
D O I：
10.1016/j.jneuroim.2023.578272
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant - DR, vs. drug-sensitive - DS). Patients with epilepsy showed higher levels of serum CCL2, CCL3, IL-8 and AOPP, and lower levels of FRAP and thiols compared to healthy controls (HC). Although none of the serum biomarkers distinguished DR from DS patients, when analysing intracellular cytokines after in vitro stimulation, DR patients presented higher percentages of IL-1 beta and IL-6 positive monocytes compared to DS patients and HC. Circulating innate immune cells might be implicated in DR epilepsy and constitute potential new targets for treatments.
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页数：11
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