Identification of a novel macrophage-related prognostic signature in colorectal cancer

被引：5

作者：

Lin, Dongfa ^{[1
,2
,3
]}

Zheng, Tingjin ^{[4
]}

Huang, Shangyuan ^{[5
]}

Liu, Rui ^{[3
]}

Guan, Shuwen ^{[1
,2
,3
]}

Zhang, Zhishan ^{[4
]}

机构：

[1] Jilin Univ, Sch Life Sci, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130012, Peoples R China

[2] Jilin Univ, Engn Lab AIDS Vaccine, Changchun 130012, Peoples R China

[3] Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China

[4] Fujian Med Univ, Quanzhou Hosp 1, Dept Clin Lab, 248 East St, Quanzhou 362000, Fujian, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Sheng Yushou Ctr Cell Biol & Immunol, Lab Mol Neurobiol,Dept Genet & Dev Biol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; NECROSIS-FACTOR; COLON-CANCER; EXPRESSION; METALLOPROTEASE; DISINTEGRIN; MUTATIONS; REGULATOR; PACKAGE; MARKERS;

D O I：

10.1038/s41598-024-53207-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Colorectal cancer (CRC) is one of the most prevalent and deadliest illnesses all around the world. Growing proofs demonstrate that tumor-associated macrophages (TAMs) are of critical importance in CRC pathogenesis, but their mechanisms remain yet unknown. The current research was designed to recognize underlying biomarkers associated with TAMs in CRC. We screened macrophage-related gene modules through WGCNA, selected hub genes utilizing the LASSO algorithm and COX regression, and established a model. External validation was performed by expression analysis using datasets GSE14333, GSE74602, and GSE87211. After validating the bioinformatics results using real-time quantitative reverse transcription PCR, we identified SPP1, C5AR1, MMP3, TIMP1, ADAM8 as potential biomarkers associated with macrophages in CRC.

引用

页数：25

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