Three-Dimensional Bioprinting in Vascular Tissue Engineering and Tissue Vascularization of Cardiovascular Diseases

In the 21st century, significant progress has been made in repairing damaged materials through material engineering. However, the creation of large-scale artificial materials still faces a major challenge in achieving proper vascularization. To address this issue, researchers have turned to biomaterials and three-dimensional (3D) bioprinting techniques, which allow for the combination of multiple biomaterials with improved mechanical and biological properties that mimic natural materials. Hydrogels, known for their ability to support living cells and biological components, have played a crucial role in this research. Among the recent developments, 3D bioprinting has emerged as a promising tool for constructing hybrid scaffolds. However, there are several challenges in the field of bioprinting, including the need for nanoscale biomimicry, the formulation of hydrogel blends, and the ongoing complexity of vascularizing biomaterials, which requires further research. On a positive note, 3D bioprinting offers a solution to the vascularization problem due to its precise spatial control, scalability, and reproducibility compared with traditional fabrication methods. This paper aims at examining the recent advancements in 3D bioprinting technology for creating blood vessels, vasculature, and vascularized materials. It provides a comprehensive overview of the progress made and discusses the limitations and challenges faced in current 3D bioprinting of vascularized tissues. In addition, the paper highlights the future research directions focusing on the development of 3D bioprinting techniques and bioinks for creating functional materials. Impact statement The utilization of three-dimensional (3D) bioprinting techniques for creating blood vessels has significantly enhanced the performance and compatibility of cardiac system blood vessels for diagnosing cardiovascular diseases. Extensive research and experimentation have demonstrated the potential of 3D-bioprinted blood vessels to enhance the health of individuals dealing with cardiovascular issues. This review offers a thorough exploration of the methods used for 3D bioprinting biomaterials tailored for the cardiac system. It also discusses the various challenges encountered in different 3D bioprinting approaches and outlines potential future advancements aimed at enhancing the 3D bioprinting of blood vessels to improve human well-being.