Use of Upadacitinib in 16 Tofacitinib-refractory Ulcerative Colitis Patients: A Single-center Case 2Series

被引：5

作者：

Levine, Jake ^{[1
]}

McKibbin, Jey ^{[2
]}

Ham, Rebecca ^{[2
]}

Cohen-Mekelburg, Shirley ^{[1
,3
,4
,5
]}

Bishu, Shrinivas ^{[1
,3
]}

Tang, Kevin ^{[3
]}

Higgins, Peter D. R. ^{[1
,3
]}

Berinstein, Jeffrey A. ^{[1
,3
,4
,6
]}

机构：

[1] Michigan Med, Dept Internal Med, Ann Arbor, MI USA

[2] Michigan Med, Dept Pharm Serv, Ann Arbor, MI USA

[3] Michigan Med, Div Gastroenterol & Hepatol, Ann Arbor, MI USA

[4] Univ Michigan, Inst Healthcare Policy & Innovat, Ann Arbor, MI USA

[5] VA Ann Arbor Hlth Care Syst, VA Ctr Clin Management Res, Ann Arbor, MI USA

[6] 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2023年 / 30卷 / 11期

关键词：

ulcerative colitis; tofacitinib; upadacitinib;

D O I：

10.1093/ibd/izad279

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We present a case series of 16 patients with ulcerative colitis who received upadacitinib after failing tofacitinib. Five patients (36%) achieved steroid-free clinical remission. Five (62%) demonstrated endoscopic response, while 2 patients (25%) achieved endoscopic remission. Adverse events were low.

引用

页码：2232 / 2235

页数：4

共 8 条

[1] Efficacy and Safety of Dual Targeted Therapy for Partially or Non-responsive Inflammatory Bowel Disease: A Systematic Review of the Literature
Berinstein, Elliot M.
Sheehan, Jessica L.
Jacob, Janson
Steiner, Calen A.
Stidham, Ryan W.
Shannon, Carol
Bishu, Shrinivas
Levine, Jacob
Cohen-Mekelburg, Shirley A.
Waljee, Akbar K.
Higgins, Peter D. R.
Berinstein, Jeffrey A.
[J]. DIGESTIVE DISEASES AND SCIENCES, 2023, 68 (06) : 2604 - 2623
[2] Efficacy of biological therapies and small molecules in moderate to severe ulcerative colitis: systematic review and network meta-analysis
Burr, Nicholas E.
Gracie, David J.
Black, Christopher J.
Ford, Alexander C.
[J]. GUT, 2022, 71 (10) : 1976 - +
[3] Danese S, 2022, LANCET, V399, P2113, DOI [10.1016/S0140-6736(22)00581-5, 10.1016/s0140-6736(22)00581-5]
[4] Upadacitinib Is Effective and Safe in Both Ulcerative Colitis and Crohn's Disease: Prospective Real-World Experience
Friedberg, Scott
Choi, David
Hunold, Thomas
Choi, Natalie K.
Garcia, Nicole M.
Picker, Emma A.
Cohen, Nathaniel A.
Cohen, Russell D.
Dalal, Sushila R.
Pekow, Joel
Sakuraba, Atsushi
Cleveland, Noa Krugliak
Rubin, David T.
[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2023, 21 (07) : 1913 - +
[5] Primary Failure to an Anti-TNF Agent in Inflammatory Bowel Disease: Switch (to a Second Anti-TNF Agent) or Swap (for Another Mechanism of Action)?
Gisbert, Javier P.
Chaparro, Maria
[J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (22)
[6] Article Topic: Positioning Ulcerative Colitis Therapies in 2022 and Beyond
Hans A.
Battat R.
Lukin D.J.
[J]. Current Gastroenterology Reports, 2022, 24 (12) : 157 - 170
[7] ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment
Raine, Tim
Bonovas, Stefanos
Burisch, Johan
Kucharzik, Torsten
Adamina, Michel
Annese, Vito
Bachmann, Oliver
Bettenworth, Dominik
Chaparro, Maria
Czuber-Dochan, Wladyslawa
Eder, Piotr
Ellul, Pierre
Fidalgo, Catarina
Fiorino, Gionata
Gionchetti, Paolo
Gisbert, Javier P.
Gordon, Hannah
Hedin, Charlotte
Holubar, Stefan
Iacucci, Marietta
Karmiris, Konstantinos
Katsanos, Konstantinos
Kopylov, Uri
Lakatos, Peter L.
Lytras, Theodore
Lyutakov, Ivan
Noor, Nurulamin
Pellino, Gianluca
Piovani, Daniele
Savarino, Edoardo
Selvaggi, Francesco
Verstockt, Bram
Spinelli, Antonino
Panis, Yves
Doherty, Glen
[J]. JOURNAL OF CROHNS & COLITIS, 2022, 16 (01) : 2 - 17
[8] ACG Clinical Guideline: Ulcerative Colitis in Adults
Rubin, David T.
Ananthakrishnan, Ashwin N.
Siegel, Corey A.
Sauer, Bryan G.
Long, Millie D.
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (03) : 384 - 413

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