Obstructive sleep apnea and non-dipper: epiphenomena or risks of Alzheimer's disease?: a review from the HOPE Asia Network

被引:4
作者
Nagai, Michiaki [1 ,2 ]
Dote, Keigo [2 ]
Park, Sungha [3 ]
Turana, Yuda [4 ]
Buranakitjaroen, Peera [5 ]
Cheng, Hao-Min [6 ,7 ,8 ,9 ,10 ]
Soenarta, Arieska Ann [11 ]
Li, Yan [12 ]
Kario, Kazuomi [13 ]
机构
[1] Univ Oklahoma, Heart Rhythm Inst, Dept Internal Med, Cardiovasc Sect,Hlth Sci Ctr, Oklahoma City, OK 73106 USA
[2] Hiroshima City Asa Hosp, Dept Cardiol, Hiroshima, Japan
[3] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea
[4] Atma Jaya Catholic Univ Indonesia, Sch Med & Hlth Sci, Dept Neurol, Jakarta, Indonesia
[5] Mahidol Univ, Fac Med, Dept Med, Div Hypertens,Siriraj Hosp, Bangkok, Thailand
[6] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Sch Med, Taipei, Taiwan
[7] Natl Yang Ming Chiao Tung Univ, Community Med Res Ctr, Sch Med, Taipei, Taiwan
[8] Taipei Vet Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan
[9] Natl Yang Ming Chiao Tung Univ, PhD Program Interdisciplinary Med PIM, Coll Med, Taipei, Taiwan
[10] Taipei Vet Gen Hosp, Ctr Evidence Based Med, Dept Med Educ, Taipei, Taiwan
[11] Univ Indonesia, Fac Med, Natl Cardiovasc Ctr, Dept Cardiol & Vasc Med, Jakarta, Indonesia
[12] Shanghai Jiao Tong Univ, Dept Cardiovasc Med, Shanghai Inst,Hypertens Ruijin Hosp, Sch Med, Shanghai, Peoples R China
[13] Jichi Med Univ, Dept Med, Div Cardiovasc Med, Sch Med, Tochigi, Japan
关键词
Alzheimer's disease; Autonomic nervous system; Insular cortex; Neurodegenerative disease; Non-dipper; Sleep apnea; POSITIVE AIRWAY PRESSURE; AMBULATORY BLOOD-PRESSURE; INSULAR CORTEX; INDEPENDENT DETERMINANT; COGNITIVE FUNCTION; HYPERTENSION; AGE; VARIABILITY; PATHOLOGY; PATTERNS;
D O I
10.1038/s41440-023-01440-6
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Obstructive sleep apnea (OSA) and associated nocturnal blood pressure (BP) surges is associated with non-dipper. On the other hand, the relationship between neurodegenerative diseases and non-dipper hypertension has been reported. To date, few studies have evaluated the relationships of nocturnal BP dipping patterns and OSA in relation to neurodegenerative diseases, particularly Alzheimer's disease (AD). This review examines the etiology of the association between OSA and the non-dipper pattern of hypertension and how both are involved in the development of AD. To set the stage for this review, we first focus on the pathophysiology of AD, which is interrelated with sleep apnea and non-dipper through dysregulation of central autonomic network.
引用
收藏
页码:271 / 280
页数:10
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