Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

被引：67

作者：

Fonseca, Alexia Del Campo ^{[1
]}

Gluck, Chaim ^{[2
,3
]}

Droux, Jeanne ^{[3
,4
,5
,6
]}

Ferry, Yann ^{[1
]}

Frei, Carole ^{[1
]}

Wegener, Susanne ^{[3
,4
,5
,6
]}

Weber, Bruno ^{[2
,3
]}

El Amki, Mohamad ^{[3
,4
,5
,6
]}

Ahmed, Daniel ^{[1
]}

机构：

[1] ETH, Dept Mech & Proc Engn, Acoust Robot Syst Lab, Saumerstr 4, CH-8803 Ruschlikon, Switzerland

[2] Univ Zurich, Inst Pharmacol & Toxicol, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Neurosci Ctr Zurich, ETH Zurich, Zurich, Switzerland

[4] Univ Hosp, Dept Neurol, CH-8091 Zurich, Switzerland

[5] Univ Zurich, CH-8091 Zurich, Switzerland

[6] Zurich Neurosci Ctr, CH-8091 Zurich, Switzerland

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

欧洲研究理事会;

关键词：

DRUG-DELIVERY; INTERSTITIAL HYPERTHERMIA; PARKINSONS-DISEASE; IN-VIVO; STRATEGIES; APPLICATORS; THERAPY; SYSTEMS;

D O I：

10.1038/s41467-023-41557-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intricate and delicate anatomy of the brain poses significant challenges for the treatment of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in hard-to-reach brain regions remains an urgent medical need. Microrobots offer potential solutions; however, their functionality in the brain remains restricted by limited imaging capabilities and complications within blood vessels, such as high blood flows, osmotic pressures, and cellular responses. Here, we introduce ultrasound-activated microrobots for in vivo navigation in brain vasculature. Our microrobots consist of lipid-shelled microbubbles that autonomously aggregate and propel under ultrasound irradiation. We investigate their capacities in vitro within microfluidic-based vasculatures and in vivo within vessels of a living mouse brain. These microrobots self-assemble and execute upstream motion in brain vasculature, achieving velocities up to 1.5 mu m/s and moving against blood flows of similar to 10 mm/s. This work represents a substantial advance towards the therapeutic application of microrobots within the complex brain vasculature.

引用

页数：14

共 69 条

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